CRYSTALLIZATION INDUCED ASYMMETRIC TRANSFORMATION - SYNTHESIS OF D-P-HYDROXYPHENYLGLYCINE

被引：12
作者：
BHATTACHARYA, A
ARAULLOMCADAMS, C
MEIER, MB
机构：
[1] Hoechst Celanese Corporation, Corpus Christi Technical Center, Corpus Christi, Texas 78469
来源：
SYNTHETIC COMMUNICATIONS | 1994年 / 24卷 / 17期
关键词：
D O I：
10.1080/00397919408010553
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
D-p-hydroxyphenylglycine (D-HPG) is prepared from racemic HPG via salicylaldehyde mediated resolution-racemization of the corresponding D-3-bromocamphor-8-sulfonate salt in acetic acid. After slurry purification to improve the de to >99.9%, the crystallized salt is neutralized to produce D-HPG in 92% overall yield and 99.9% ee.
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页码：2449 / 2459
页数：11
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