TISSUE DRUG RESIDUE EXTRACTION AND MONITORING BY MATRIX SOLID-PHASE DISPERSION (MSPD)-HPLC ANALYSIS

The increasing implementation of immuno-, receptor and microbial inhibition screening tests for the monitoring of drug residues in foods of animal origin also requires that we be capable of confirming and validating the results of such tests in a timely manner. Methodology for the isolation and analysis of "detected" substances must be capable of performing rapid and efficient extractions that are amenable to instrumental determinations for the presence, level and, where possible, identity of the substance in question. We present here a summary of such methodolgy utilizing matrix solid phase dispersion (MSPD) as the . isolation method and several simple isocratic HPLC/UV diode array and florescence methods developed for extracts so obtained for several drug classes as well as individual drugs. The application of these methods for a variety of purposes in drug residue monitoring programs is discussed.