SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF NOVEL AMINO-PROSTANOIDS - POTENT AND ORALLY EFFECTIVE THROMBOXANE A2 RECEPTOR ANTAGONISTS

被引：2

作者：

CAMPBELL, IB ^{[1
]}

COLLINGTON, EW ^{[1
]}

FINCH, H ^{[1
]}

HALLETT, P ^{[1
]}

HAYES, R ^{[1
]}

LUMLEY, P ^{[1
]}

MILLS, K ^{[1
]}

WALLIS, CJ ^{[1
]}

WHITE, BP ^{[1
]}

机构：

[1] GLAXO GRP RES LTD,DEPT PERIPHERAL PHARMACOL,WARE SG12 ODP,HERTS,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(01)81049-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Modification of the thromboxane receptor antagonist, GR 32191, has led to a series of readily synthesised amino-prostanoids. The most effective compound is GR 70067, an orally active agent that may be useful in the treatment of thrombotic disease.

引用

页码：689 / 694

页数：6