ACTIVATION OF METABOTROPIC RECEPTORS HAS A NEUROPROTECTIVE EFFECT IN A RODENT MODEL OF FOCAL ISCHEMIA

被引：90

作者：

CHIAMULERA, C

ALBERTINI, P

VALERIO, E

REGGIANI, A

机构：

[1] Glaxo Research Laboratories, Verona

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 216卷 / 02期

关键词：

EXCITATORY AMINO ACIDS; METABOTROPIC RECEPTORS; CEREBRAL ISCHEMIA;

D O I：

10.1016/0014-2999(92)90382-E

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The role of the glutamate 'metabotropic' receptor was investigated in an experimental model of focal ischaemia-induced neurodegeneration. The metabotropic agonist, trans-1-amino cyclopentane-1,3-dicarboxylic acid (t-ACPD, 20 mg/kg i.p.), was administered to mice immediately after middle cerebral artery occlusion (MCAO), which causes cerebral infarct. Seven days after MCAO, the mean infarct volume value of the t-ACPD-treated group (mean +/- S.E. = 4.57 +/- 0.73 mm3) was significantly reduced, by 34.3%, compared to the vehicle-treated group (mean +/- S.E. = 6.95 +/- 0.59 mm3, P < 0.01). This suggests that metabotropic receptor activation in the adult brain reduces excitotoxicity.

引用

页码：335 / 336

页数：2

共 7 条

[1] TRANS-ACPD DEPRESSES SYNAPTIC TRANSMISSION IN THE HIPPOCAMPUS [J].