INFLUENCE OF TARGET TISSUES ON THEIR INNERVATION IN OLD-AGE - A TRANSPLANTATION STUDY

被引：40

作者：

GAVAZZI, I ^{[1
]}

ANDREWS, TJ ^{[1
]}

THRASIVOULOU, C ^{[1
]}

COWEN, T ^{[1
]}

机构：

[1] ROYAL FREE HOSP, SCH MED, DEPT ANAT, ROWLAND HILL ST, LONDON NW3 2PF, ENGLAND

来源：

NEUROREPORT | 1992年 / 3卷 / 08期

基金：

英国惠康基金;

关键词：

AGING; TRANSPLANTATION; RAT; BLOOD VESSELS; INNERVATION; NEUROTROPHIC;

D O I：

10.1097/00001756-199208000-00017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

AGE-RELATED changes in the nervous system might be intrinsic to the neurons or secondary to changes in the target tissues they supply. We have investigated this question by transplanting old and young vascular muscle into contact with young host nerves in oculo and observing the reinnervating nerve fibres. The density and pattern of reinnervation were those typical of the age of the target tissue, thus old transplants imposed an 'old' pattern of reinnervation on young host nerves. Our findings strongly support the hypothesis that target tissues determine the pattern and density of their innervation in old age.

引用

页码：717 / 720

页数：4

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