EFFECT OF PERTUSSIS TOXIN ON ALPHA-2-ADRENOCEPTORS - DECREASED FORMATION OF THE HIGH-AFFINITY STATE FOR AGONISTS

被引:21
作者
GARCIASAINZ, JA
BOYER, JL
MICHEL, T
SAWYER, D
STILES, GL
DOHLMAN, H
LEFKOWITZ, RJ
机构
[1] INST NACL CARDIOL IGNACIO CHAVEZ,DEPT ENDOCRINOL,MEXICO CITY,MEXICO
[2] DUKE UNIV,MED CTR,HOWARD HUGHES MED INST,DEPT MED,DURHAM,NC 27710
关键词
D O I
10.1016/0014-5793(84)80881-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:95 / 98
页数:4
相关论文
共 21 条
[1]   ADENYLATE-CYCLASE INHIBITION AND GTPASE STIMULATION BY SOMATOSTATIN IN S49 LYMPHOMA CYC-VARIANTS ARE PREVENTED BY ISLET-ACTIVATING PROTEIN [J].
AKTORIES, K ;
SCHULTZ, G ;
JAKOBS, KH .
FEBS LETTERS, 1983, 158 (01) :169-173
[2]   ISLET-ACTIVATING PROTEIN PREVENTS NICOTINIC ACID-INDUCED GTPASE STIMULATION AND GTP BUT NOT GTP-GAMMA-S-INDUCED ADENYLATE-CYCLASE INHIBITION IN RAT ADIPOCYTES [J].
AKTORIES, K ;
SCHULTZ, G ;
JAKOBS, KH .
FEBS LETTERS, 1983, 156 (01) :88-92
[3]  
BOKOCH GM, 1983, J BIOL CHEM, V258, P2072
[4]  
BURNS DL, 1983, J BIOL CHEM, V258, P1435
[5]   PERTUSSIS TOXIN SUBSTRATE, THE PUTATIVE NI COMPONENT OF ADENYLYL CYCLASES, IS AN ALPHA-BETA-HETERODIMER REGULATED BY GUANINE-NUCLEOTIDE AND MAGNESIUM [J].
CODINA, J ;
HILDEBRANDT, J ;
IYENGAR, R ;
BIRNBAUMER, L ;
SEKURA, RD ;
MANCLARK, CR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (14) :4276-4280
[6]   SIMULTANEOUS ANALYSIS OF FAMILIES OF SIGMOIDAL CURVES - APPLICATION TO BIOASSAY, RADIOLIGAND ASSAY, AND PHYSIOLOGICAL DOSE-RESPONSE CURVES [J].
DELEAN, A ;
MUNSON, PJ ;
RODBARD, D .
AMERICAN JOURNAL OF PHYSIOLOGY, 1978, 235 (02) :E97-E102
[7]   PERTUSSIS TOXIN REVERSES GPP(NH)P INHIBITION OF BASAL AND FORSKOLIN ACTIVATED ADIPOCYTE ADENYLATE-CYCLASE [J].
FAIN, JN ;
ODONNELL, CJ ;
MILLS, I ;
GARCIASAINZ, JA .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1983, 116 (02) :651-656
[8]  
GARCIASAINZ JA, 1980, LIFE SCI, V27, P953