Galectins as therapeutic targets for hematological malignancies: a hopeful sweetness

被引：18
作者：
Pena, Camilo [1 ]
Mirandola, Leonardo [1 ,2 ]
Figueroa, Jose A. [1 ,3 ]
Hosiriluck, Nattamol [1 ]
Suvorava, Natallia [1 ]
Trotter, Kayley [1 ,3 ]
Reidy, Adair [1 ,3 ]
Rakhshanda, Rahman [4 ]
Payne, Drew [1 ]
Jenkins, Marjorie [2 ]
Grizzi, Fabio [5 ]
Littlefield, Lauren [1 ,3 ]
Chiriva-Internati, Maurizio [1 ,2 ,3 ]
Cobos, Everardo [1 ]
机构：
[1] Texas Tech Univ, Hlth Sci Ctr, Dept Internal Med, Div Hematol & Oncol, 3601 4th St.,Mail Stop 9410, Lubbock, TX 79430 USA
[2] Laura W Bush Inst Womens Hlth & Ctr Womens Hlth &, Amarillo, TX USA
[3] Kirom LLC, Amarillo, TX USA
[4] Texas Tech Univ, Med Ctr, Div Surg Oncol, Amarillo, TX USA
[5] Humanitas Clin & Res Ctr, Milan, Italy
来源：
ANNALS OF TRANSLATIONAL MEDICINE | 2014年 / 2卷 / 09期
关键词：
Galectins; galectin-3 (Gal-3); lymphomas; leukemia; multiple myeloma (MM);
D O I：
10.3978/j.issn.2305-5839.2014.09.14
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Galectins are family of galactose-binding proteins known to play critical roles in inflammation and neoplastic progression. Galectins facilitate the growth and survival of neoplastic cells by regulating their cross-talk with the extracellular microenvironment and hampering anti-neoplastic immunity. Here, we review the role of galectins in the biology of hematological malignancies and their promise as potential therapeutic agents in these diseases.
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页数：7
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