A/G polymorphism of matrix metalloproteinase 7 gene promoter region and cancer risk: A meta-analysis

被引：5

作者：

Wu, Jing ^{[1
]}

Guan, Xuan ^{[2
]}

Zhang, Kui ^{[3
]}

Li, Ya-Ting ^{[1
]}

Bai, Peng ^{[3
]}

Wu, Jin ^{[1
]}

机构：

[1] Sichuan Univ, West China Sch Preclin & Forens Med, Dept Forens Biol, 17 South Renmin Rd, Chengdu 610041, Sichuan, Peoples R China

[2] Chengdu Med Coll, Sch Basic Med Sci, Chengdu 610500, Sichuan, Peoples R China

[3] Sichuan Univ, West China Univ Hosp 2, Lab Mol Translat Med, Chengdu 610041, Sichuan, Peoples R China

来源：

BIOMEDICAL REPORTS | 2013年 / 1卷 / 05期

关键词：

polymorphism; matrix metalloproteinase; cancer risk; meta-analysis;

D O I：

10.3892/br.2013.131

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

This meta-analysis was conducted to evaluate the effect of the matrix metalloproteinase 7 (MMP7)-181A/G polymorphism on cancer risk. Twenty-seven case-control studies were identified via a literature search through PubMed, Web of Science and China National Knowledge Infrastructure databases. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were applied to assess the strength of the association between MMP7-181A/G polymorphism and cancer risk. The 27 studies were further assessed according to Hardy-Weinberg equilibrium (HWE) and Hardy-Weinberg disequilibrium (HWD), with 24 case-control studies found to be under HWE. A significant association was observed between MMP7-181A/G polymorphism and increased cancer risk (cervical and other types of cancer) in Asian, but not in European populations.

引用

页码：792 / 796

页数：5

共 36 条

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