ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF STREPTOMYCES SP. VITDDK3 ISOLATED FROM ENNORE COAST, TAMIL NADU, INDIA

被引：0
作者：
Deepika, Lakshmipathy [1 ]
Kannabiran, Krishnan [1 ]
机构：
[1] VIT Univ, Sch Biosci & Technol, Div Biomol & Genet, Vellore 632014, Tamil Nadu, India
来源：
ASIAN JOURNAL OF PHARMACEUTICAL RESEARCH AND HEALTH CARE | 2010年 / 2卷 / 02期
关键词：
Streptomyces sp. VITDDK3; antibacterial activity; antifungal activity; chemotaxonomy; phylogenetic analysis;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Actinobacteria isolated from soil samples collected at the Ennore saltern, Tamil Nadu was screened for antibacterial and antifungal activity against common clinical pathogens. The isolate VITDDK3 exhibited more promising antagonistic activity against Escherichia coli, Pseudomonas aeruginosa, Aspergillus flavus and Aspergillus fumigatus. Presence of LL-Diaminopimelic acid and glycine assigned the isolate VITDDK3 to the genus Streptomyces. Further 16S rRNA partial gene sequence was carried out to confirm the chemotaxonomic results. BLAST analysis showed that the strain VITDDK3 possessed 98% similarity with Streptomyces sp. A254YdzZZ but phylogenetic analysis revealed that its closest neighbour was Streptomyces tricolor HBUM175176. The rRNA secondary structure and the restriction sites of VITDDK3 were predicted using Genebee and NEBCutter online softwares respectively.
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页码：188 / 196
页数：9
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