DRUG-OLIGONUCLEOTIDE CONJUGATES

被引：10
|
作者：
BYRN, SR
CARLSON, DV
CHEN, JK
CUSHMAN, MS
GOLDMAN, ME
MA, WP
PIDGEON, CL
RAY, KA
STOWELL, JG
WEITH, HL
机构：
[1] PURDUE UNIV,SCH PHARM & PHARM SCI,DEPT MED CHEM & PHARMACOGNOSY,W LAFAYETTE,IN 47907
[2] MERCK SHARP & DOHME LTD,DEPT NEW LEAD PHARMACOL,W POINT,PA 19486
来源：
ADVANCED DRUG DELIVERY REVIEWS | 1991年 / 6卷 / 03期
关键词：
ACRIDINE - ATTACHED TO OLIGONUCLEOTIDES; ALKALOID - ATTACHED TO OLIGONUCLEOTIDES; ANTISENSE - OLIGONUCLEOTIDE-DRUG CONJUGATES; BENZOPHENANTHRIDINE; CONJUGATE - OLIGONUCLEOTIDES LINKED TO DRUGS; DRUG - OLIGONUCLEOTIDE CONJUGATES; INTERCALATOR - DRUG-OLIGONUCLEOTIDE CONJUGATES; LINKER - DRUGS ATTACHED TO OLIGONUCLEOTIDES; LIPOSOME - DELIVERY OF ANTISENSE OLIGONUCLEOTIDE CONJUGATES; OLIGONUCLEOTIDE - DRUG-LINKED ANTISENSE CONJUGATES; PHOSPHORAMIDITE; REVERSE TRANSCRIPTASE ASSAY;
D O I：
10.1016/0169-409X(91)90022-5
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In this review, drug oligonucleotide conjugates synthesized and characterized in our laboratories will be discussed. An idealized view of a complex between an acridine-oligonucleotide conjugate and RNA is shown above. In addition, other related conjugates will be reviewed. The goal of this review is to establish that it is now feasible to synthesize a wide range of drug oligonucleotide conjugates. The testing of these molecules will provide important information on the pharmacological usefulness of targeting drugs to specific sequences using oligonucleotides.
引用
收藏
页码：287 / 308
页数：22
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