SYNTHESIS AND EVALUATION OF POTENTIAL PHARMACOPHORES DERIVED FROM 4-OXO-4H-1-BENZOPYRAN-3-CARBOXYLDEHYDE

被引：0

作者：

COUTINHO, DLM ^{[1
]}

FERNANDES, PS ^{[1
]}

机构：

[1] ST XAVIERS COLL,DEPT CHEM,NSR LAB,BOMBAY 400001,INDIA

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 1992年 / 31卷 / 09期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of hydrazone derivatives of 4-oxo-4H-1-benzopyran-3-carboxaldehyde (2a-c, 4a-c, 5, 6a,b), 3-aryl-1-(benzopyran-4-one-3-yl)propen-3-one (8a-c), ethyl 2-cyano-3-(benzopyran-4-one-3-yl)acrylate (10) and thioacetal derivatives of 4-oxo-4H-1-benzopyran-3-carboxaldehyde (12a,b) are reported. Ring transformation of these derivatives furnish 1-aryl-4-(2-hydroxybenzoyl)pyrazoles (3a,b),4-(2-hydroxybenzoyl)-1H-pyrazole(7),2-aryl-5-2-hydroxybenzoyl)pyridines (9a-c) and ethyl 5-(2-hydroxybenzoyl)pyrid-2-one-3-carboxylate (11) which can also be prepared in a single step from 4-oxo-4H-1-benzopyran-3-carboxylaldehyde (1). Preliminary investigations indicate antimicrobial activity for several compounds.

引用

页码：573 / 577

页数：5

共 11 条

[1]

BRADSHAW LJ, 1979, LABORATORY MICROBIOL

[2]

Cox J S, 1970, Adv Drug Res, V5, P115

[3] DISODIUM CROMOGLYCATE (FPL 670) (INTAL) - A SPECIFIC INHIBITOR OF REAGINIC ANTIBODY-ANTIGEN MECHANISMS [J].

COX, JSG .

NATURE, 1967, 216 (5122) :1328-&

[4]

FERNANDES PS, 1983, J INDIAN CHEM SOC, V60, P864

[5]

FERNANDES PS, 1983, J INDIAN CHEM SOC, V60, P156

[6]

FERNANDES PS, 1991, INDIAN J HETEROCYCL, V1, P103

[7]

FERNANDES PS, 1983, J INDIAN CHEM SOC, V60, P987

[8]

FERNANDES PS, IN PRESS J INDIAN CH

[9]

Gabors M, 1972, ANTIINFLAMMATORY ACT

[10] STUDIES ON ANTIANAPHYLACTIC AGENTS .1. FACILE SYNTHESIS OF 4-OXO-4H-1-BENZOPYRAN-3-CARBOXALDEHYDES BY VILSMEIER REAGENTS [J].

NOHARA, A ;

UMETANI, T ;

SANNO, Y .

TETRAHEDRON, 1974, 30 (19) :3553-3561

← 1 2 →