Osteoprotegerin: a valid new marker of bone turnover in post-menopausal osteoporosis?

被引：2
|
作者：
Ulivieri, F. M. [1 ]
Piodi, L. P. [2 ]
Marchelli, D. [1 ]
Corradini, C. [3 ]
Verdoia, C. [3 ]
Gherardi, P. Gerundini [1 ]
机构：
[1] IRCCS Major Hosp Milan, Nucl Med Unit, F Sforza 35\, I-20122 Milan, Italy
[2] IRCCS Major Hosp, Gastroenterol Dept, Milan, Italy
[3] Univ Milan, Orthopaed & Traumatol Clin, Milan, Italy
来源：
JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY | 2005年 / 6卷 / 02期
关键词：
Bone mineral density; Bone turnover markers; Osteoprotegerin; Post-menopausal osteoporosis;
D O I：
10.1007/s10195-005-0087-4
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
An increase of setum osteoprotegerin has been found in post-menopausal women, that is positively correlated with age and bone markers, negatively with bone mass. In 25 post-menopausal women (mean age, 63 +/- 8 years) we measured serum levels of osteoprotegerin, total and bone alkaline phosphatase, osteocalcin, urinary deoxypyridinoline and bone mineral density of the lumbar spine and femur. Osteoprotegerin and bone markers did not differ from range of normal values. Bone mineral density appeared markedly reduced both at the spine and the femur. A significant correlation between osteoprotegerin and age, duration of menopause, osteocalcin and bone alkaline phosphatase was found. No correlation was found between osteoprotegerin and bone mineral density in all measured skeletal sites. In conclusion, osteoprotegerin does not appear to be an interesting parameter for the evaluation of bone turnover in post-menopausal osteoporosis.
引用
收藏
页码：88 / 90
页数：3
相关论文
共 50 条
  • [1] CLINICAL APPLICATION OF BONE TURNOVER MARKERS IN POST-MENOPAUSAL OSTEOPOROSIS
    Lorentzon, M.
    Branco, J.
    Brandi, M. L.
    Bruyere, O.
    Chapurlat, R.
    Cooper, C.
    Cortet, B.
    Diez-Perez, A.
    Ferrari, S.
    Gasparik, A.
    Herrman, M.
    Jorgensen, N. R.
    Kanis, J. A.
    Kaufman, J. -M.
    Laslop, A.
    Locquet, M.
    Matijevic, R.
    Mccloskey, E. V.
    Minisola, S.
    Pikner, R.
    Reginster, J. -Y.
    Rizzoli, R.
    Szulc, P.
    Vlaskovska, M.
    Cavalier, E.
    OSTEOPOROSIS INTERNATIONAL, 2020, 31 (SUPPL 1) : S65 - S66
  • [2] Bone mineral density and serum osteoprotegerin in post-menopausal women with or without osteoporosis
    Ardawi, M. S.
    Nasrat, H. A.
    Bahksh, T. M.
    Maimany, A. A.
    Rouzi, A. A.
    BONE, 2007, 40 (06) : S193 - S194
  • [3] Bone remodeling in post-menopausal osteoporosis
    Lerner, U. H.
    JOURNAL OF DENTAL RESEARCH, 2006, 85 (07) : 584 - 595
  • [4] Serum Osteoprotegerin and Bone Mineral Density in Post-Menopausal Women with or without Osteoporosis.
    Rouzi, Abdulrahim A.
    Ardawi, Mohammed S.
    Baksh, Talal M.
    Maimany, Abdulraof A.
    Qari, Mohammed H.
    REPRODUCTIVE SCIENCES, 2010, 17 (03) : 269A - 269A
  • [5] The use of biochemical markers of bone turnover in the management of post-menopausal osteoporosis - Foreword
    Rizzoli, R
    OSTEOPOROSIS INTERNATIONAL, 2000, 11 : 1 - 1
  • [6] ASSESSMENT OF BONE TURNOVER IN POST-MENOPAUSAL OSTEOPOROSIS BY MEASUREMENT OF SERUM BONE GLA-PROTEIN
    DELMAS, PD
    WAHNER, HW
    MANN, KG
    RIGGS, BL
    JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 1983, 102 (04): : 470 - 476
  • [7] PTH 1-84 and bone turnover markers in severe post-menopausal osteoporosis
    Pastore, R.
    Borboni, P.
    Vancieri, G.
    Mentuccia, D.
    Di Giacinto, P.
    Frajese, G. V.
    BONE, 2011, 48 : S229 - S229
  • [8] POST-MENOPAUSAL OSTEOPOROSIS
    AITKEN, JM
    BRITISH MEDICAL JOURNAL, 1982, 285 (6354): : 1577 - 1577
  • [9] POST-MENOPAUSAL OSTEOPOROSIS
    RAI, GS
    BRITISH MEDICAL JOURNAL, 1982, 285 (6344): : 808 - 808
  • [10] Post-menopausal osteoporosis
    Marcus, R
    BEST PRACTICE & RESEARCH IN CLINICAL OBSTETRICS & GYNAECOLOGY, 2002, 16 (03): : 309 - 327
12345