MILD CONDITIONS FOR THE PREPARATION OF HIGH-MANNOSE OLIGOSACCHARIDE OXAZOLINES - ENTRY POINT FOR BETA-GLYCOSIDE AND NEOGLYCOPROTEIN SYNTHESES(1)

被引：19

作者：

COLON, M ^{[1
]}

STAVESKI, MM ^{[1
]}

DAVIS, JT ^{[1
]}

机构：

[1] GENZYME CORP,DEPT CHEM,CAMBRIDGE,MA 02139

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 35期

关键词：

D O I：

10.1016/0040-4039(91)80008-T

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An equimolar mixture of BF3:OEt2 and TMSBr was found to be an excellent promoter for the formation of 1,2-beta-oxazolines from peracetate derivatives of the acid-labile high-mannose oligosaccharides Man6-8GlcNAc. The oxazolines are accessible from both beta and alpha anomers of the starting oligosaccharide peracetate, and are valuable precursors for the subsequent synthesis of structurally complex glycoconjugates.

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页码：4447 / 4450

页数：4

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