U-87947E, A POTENT QUINOLONE ANTIBACTERIAL AGENT INCORPORATING A BICYCLO[1.1.1]PENT-1-YL (BCP) SUBUNIT

被引：35

作者：

BARBACHYN, MR ^{[1
]}

HUTCHINSON, DK ^{[1
]}

TOOPS, DS ^{[1
]}

REID, RJ ^{[1
]}

ZURENKO, GE ^{[1
]}

YAGI, BH ^{[1
]}

SCHAADT, RD ^{[1
]}

ALLISON, JW ^{[1
]}

机构：

[1] UPJOHN CO,CANC & INFECT DIS RES,KALAMAZOO,MI 49001

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(01)81251-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Incorporation of a bicyclo[ 1. 1. I]pent-1-yl group at the N-1 position of quinolone antibacterial agents affords compounds with potent activity. One of these analogs, U-87947E, exhibits enhanced activity relative to that of ciprofloxacin against gram-positive aerobic bacteria and anaerobic organisms. Time-kill kinetic studies reveal that U-87947E is exquisitely bactericidal against ciprofloxacin-resistant Staphylococcus aureus.

引用

页码：671 / 676

页数：6

共 23 条

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[2]

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[3]

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