EFFECT OF GLUTATHIONE AEROSOL ON OXIDANT-ANTIOXIDANT IMBALANCE IN IDIOPATHIC PULMONARY FIBROSIS

被引:172
作者
BOROK, Z
BUHL, R
GRIMES, GJ
BOKSER, AD
HUBBARD, RC
HOLROYD, KJ
ROUM, JH
CZERSKI, DB
CANTIN, AM
CRYSTAL, RG
机构
[1] NHLBI,PULM BRANCH,BLDG 10 ROOM 6D03,BETHESDA,MD 20892
[2] NIH,CTR CLIN,DEPT PHARM,BETHESDA,MD 20892
[3] CHU SHERBROOKE,SERV PNEUMOL,SHERBROOKE J1H 5N4,QUEBEC,CANADA
关键词
D O I
10.1016/0140-6736(91)90350-X
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Idiopathic pulmonary fibrosis (IPF) is characterised by alveolar inflammation, exaggerated release of oxidants, and subnormal concentrations of the antioxidant glutathione in respiratory epithelial lining fluid (ELF). Glutathione (600 mg twice daily for 3 days) was given by aerosol to 10 patients with IPF. Total ELF glutathione rose transiently, ELF oxidised glutathione concentrations increased, and there was a decrease in spontaneous superoxide anion release by alveolar macrophages. Thus, glutathione by aerosol could be a means of reversing the oxidant-antioxidant imbalance in IPF.
引用
收藏
页码:215 / 216
页数:2
相关论文
共 10 条
[1]   AUGMENTATION OF GLUTATHIONE IN THE FLUID LINING THE EPITHELIUM OF THE LOWER RESPIRATORY-TRACT BY DIRECTLY ADMINISTERING GLUTATHIONE AEROSOL [J].
BUHL, R ;
VOGELMEIER, C ;
CRITENDEN, M ;
HUBBARD, RC ;
HOYT, RF ;
WILSON, EM ;
CANTIN, AM ;
CRYSTAL, RG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (11) :4063-4067
[2]  
BUHL R, 1989, LANCET, V2, P1294
[3]   GLUTATHIONE DEFICIENCY IN THE EPITHELIAL LINING FLUID OF THE LOWER RESPIRATORY-TRACT IN IDIOPATHIC PULMONARY FIBROSIS [J].
CANTIN, AM ;
HUBBARD, RC ;
CRYSTAL, RG .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1989, 139 (02) :370-372
[4]   OXIDANT-MEDIATED EPITHELIAL-CELL INJURY IN IDIOPATHIC PULMONARY FIBROSIS [J].
CANTIN, AM ;
NORTH, SL ;
FELLS, GA ;
HUBBARD, RC ;
CRYSTAL, RG .
JOURNAL OF CLINICAL INVESTIGATION, 1987, 79 (06) :1665-1673
[5]   INTERSTITIAL LUNG-DISEASES OF UNKNOWN CAUSE - DISORDERS CHARACTERIZED BY CHRONIC INFLAMMATION OF THE LOWER RESPIRATORY-TRACT .2. [J].
CRYSTAL, RG ;
BITTERMAN, PB ;
RENNARD, SI ;
HANCE, AJ ;
KEOGH, BA .
NEW ENGLAND JOURNAL OF MEDICINE, 1984, 310 (04) :235-244
[6]   INTERSTITIAL LUNG-DISEASES OF UNKNOWN CAUSE .1. DISORDERS CHARACTERIZED BY CHRONIC INFLAMMATION OF THE LOWER RESPIRATORY-TRACT [J].
CRYSTAL, RG ;
BITTERMAN, PB ;
RENNARD, SI ;
HANCE, AJ ;
KEOGH, BA .
NEW ENGLAND JOURNAL OF MEDICINE, 1984, 310 (03) :154-166
[7]   PROTECTION OF ALVEOLAR MACROPHAGES FROM HYPEROXIA BY GAMMA-GLUTAMYL TRANSPEPTIDASE [J].
FORMAN, HJ ;
SKELTON, DC .
AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 259 (02) :L102-L107
[8]  
MEISTER A, 1988, J BIOL CHEM, V263, P17205
[9]  
SIES H, 1984, METHOD ENZYMOL, V105, P445
[10]   CRYPTOGENIC FIBROSING ALVEOLITIS - CLINICAL-FEATURES AND THEIR INFLUENCE ON SURVIVAL [J].
TURNERWARWICK, M ;
BURROWS, B ;
JOHNSON, A .
THORAX, 1980, 35 (03) :171-180