EFFECT OF GLUTATHIONE AEROSOL ON OXIDANT-ANTIOXIDANT IMBALANCE IN IDIOPATHIC PULMONARY FIBROSIS

被引：173

作者：

BOROK, Z

BUHL, R

GRIMES, GJ

BOKSER, AD

HUBBARD, RC

HOLROYD, KJ

ROUM, JH

CZERSKI, DB

CANTIN, AM

CRYSTAL, RG

机构：

[1] NHLBI,PULM BRANCH,BLDG 10 ROOM 6D03,BETHESDA,MD 20892

[2] NIH,CTR CLIN,DEPT PHARM,BETHESDA,MD 20892

[3] CHU SHERBROOKE,SERV PNEUMOL,SHERBROOKE J1H 5N4,QUEBEC,CANADA

来源：

LANCET | 1991年 / 338卷 / 8761期

关键词：

D O I：

10.1016/0140-6736(91)90350-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Idiopathic pulmonary fibrosis (IPF) is characterised by alveolar inflammation, exaggerated release of oxidants, and subnormal concentrations of the antioxidant glutathione in respiratory epithelial lining fluid (ELF). Glutathione (600 mg twice daily for 3 days) was given by aerosol to 10 patients with IPF. Total ELF glutathione rose transiently, ELF oxidised glutathione concentrations increased, and there was a decrease in spontaneous superoxide anion release by alveolar macrophages. Thus, glutathione by aerosol could be a means of reversing the oxidant-antioxidant imbalance in IPF.

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收藏

页码：215 / 216

页数：2

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