POSTOPERATIVE RADIOTHERAPY IN CARCINOMA OF THE CERVIX - TREATMENT RESULTS AND PROGNOSTIC FACTORS

被引：23

作者：

ATKOVAR, G ^{[1
]}

UZEL, O ^{[1
]}

OZSAHIN, M ^{[1
]}

KOCA, S ^{[1
]}

SAHINLER, I ^{[1
]}

OKKAN, S ^{[1
]}

UZEL, R ^{[1
]}

机构：

[1] UNIV ISTANBUL,CERRAHPASA FAC MED,DEPT RADIAT ONCOL,ISTANBUL,TURKEY

来源：

RADIOTHERAPY AND ONCOLOGY | 1995年 / 35卷 / 03期

关键词：

POSTOPERATIVE RADIOTHERAPY; PROGNOSTIC FACTORS; CERVIX;

D O I：

10.1016/0167-8140(95)01570-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In order to assess the role of postoperative radiotherapy and prognostic factors, 126 patients who were treated with radiotherapy after surgery for clinical early-stage carcinoma of the cervix were reviewed. All patients received external pelvic radiotherapy and 37 patients were treated with additional vaginal cuff irradiation. The 5-year overall survival, disease-free survival and locoregional control rates were 71.1, 69.9 and 78.1%, respectively. The 5-year disease-free survival rates were 40% for grade 3 vs. 75.4% for grade 1 tumours (p = 0.05), 76.5% for pathological stage IB versus 54.1% for pathological stage IIA (p = 0.04), 36.6% for node-positive patients versus 82.5% for node-negative patients (p = 0.0017), 54% for full thickness cervical invasion versus 100% superficial cervical invasion (p = 0.01), 34.8% for positive margins versus 78.1 for negative margins (p < 0.0001). After a multivariate analysis, tumour grade (p = 0.026) and presence of positive margins (p = 0.006) were found to independently influence the outcome. Grade II and III complication rate was 5.5% in all patients. In conclusion, postoperative radiotherapy should be used in patients treated with simple hysterectomy as well as those treated with radical hysterectomy with unfavorable pathological findings.

引用

页码：198 / 205

页数：8

共 24 条

[1]

Ampil, Datta, Datta, Elective postoperative external radiotherapy after hysterectomy in early stage carcinoma of the cervix, Cancer, 60, pp. 280-288, (1987)

[2]

Bachaud, Fu, Delannes, Non-randomized study of irradiation alone or in combination with surgery in stage IB, IIA and proxinial IIB carcinoma of the cervix, Radiat. Oncol., 22, pp. 104-110, (1991)

[3]

Barton, Keane, Gadalla, Maki, The effect of treatment time and treatment interruptions on tumor control following radical radiotherapy of laryngeal cancer, Radiother. Oncol., 23, pp. 137-143, (1992)

[4]

Brady, Perez, Bedwinek, Failure patterns in gynecologic cancer, Int. J. Radiat. Oncol. Biol. Phys., 12, pp. 549-557, (1986)

[5]

Buchler, Petreit, Sarkaria, Et al., The adverse effect of treatment prolongation in cervical carcinoma, Int. J. Radiat. Oncol. Biol. Phys., 27, 1 S, (1993)

[6]

Coulter, Mason, Cervix and endometrium, Treatment of Cancer, pp. 45-48, (1990)

[7]

Cox, Regression models and life tables, J. Roy. Stat. Soc., 34, pp. 187-220, (1972)

[8]

Crook, Esche, Chaplin, Et al., Dose-volume analysis and the prevention of radiation sequela in cervical cancer, Radiother. Oncol., 8, pp. 321-332, (1987)

[9]

Fyles, Keane, Barton, Simm, The effect of treatment duration in local control of cervix cancer, Radiather. Oncol., 25, pp. 273-279, (1992)

[10]

Gerbaulet, Konkler, Kerr, Et al., Combined radiotherapy and surgery, local control and complications in early carcinoma of the uterine cervix: the Villejuif experience, 1975—1984, Radiather. Oncol., 23, pp. 66-73, (1992)

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