NEW STRUCTURAL MOTIFS FOR HAMMERHEAD RIBOZYMES - CATALYTIC ACTIVITY OF ABASIC NUCLEOTIDE SUBSTITUTED RIBOZYMES

被引:27
作者
BEIGELMAN, L
KARPEISKY, A
MATULICADAMIC, J
GONZALEZ, C
USMAN, N
机构
[1] RIBOZYME PHARMACEUT INC,DEPT CHEM & BIOCHEM,BOULDER,CO 80301
[2] RIBOZYME PHARMACEUT INC,DEPT ENZYMOL,BOULDER,CO 80301
来源
NUCLEOSIDES & NUCLEOTIDES | 1995年 / 14卷 / 3-5期
关键词
D O I
10.1080/15257779508012499
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The synthesis of 1-deoxy-D-ribofuranose-3-(2-cyanoethyl N,N-diisopropylphosphoramidite) (6) from D-ribose and its incorporation into a hammerhead ribozyme is described.
引用
收藏
页码:907 / 910
页数:4
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