NEW STRUCTURAL MOTIFS FOR HAMMERHEAD RIBOZYMES - CATALYTIC ACTIVITY OF ABASIC NUCLEOTIDE SUBSTITUTED RIBOZYMES

被引：27

作者：

BEIGELMAN, L

KARPEISKY, A

MATULICADAMIC, J

GONZALEZ, C

USMAN, N

机构：

[1] RIBOZYME PHARMACEUT INC,DEPT CHEM & BIOCHEM,BOULDER,CO 80301

[2] RIBOZYME PHARMACEUT INC,DEPT ENZYMOL,BOULDER,CO 80301

来源：

NUCLEOSIDES & NUCLEOTIDES | 1995年 / 14卷 / 3-5期

关键词：

D O I：

10.1080/15257779508012499

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of 1-deoxy-D-ribofuranose-3-(2-cyanoethyl N,N-diisopropylphosphoramidite) (6) from D-ribose and its incorporation into a hammerhead ribozyme is described.

引用

页码：907 / 910

页数：4

共 13 条

[1]

CECH TR, 1992, CURR OPIN STRUC BIOL, V2, P605, DOI DOI 10.1016/0959-440X(92)90093-M

[2] SYNTHESIS OF 1,2-TRANS-RELATED 1-THIOGLYCOSIDE ESTERS [J].

FERRIER, RJ ;

FURNEAUX, RH .

CARBOHYDRATE RESEARCH, 1976, 52 (DEC) :63-68

[3]

FU DJ, 1993, J AM CHEM SOC, V115, P8483

[4]

GIESE B, 1987, ANGEW CHEM INT EDIT, V28, P233

[5] ONE ELECTRON C-C BOND FORMING REACTIONS VIA ALLYLSTANNANES - SCOPE AND LIMITATIONS [J].

KECK, GE ;

ENHOLM, EJ ;

YATES, JB ;

WILEY, MR .

TETRAHEDRON, 1985, 41 (19) :4079-4094

[6] SYNTHESIS AND BIOPHYSICAL STUDIES OF SHORT OLIGODEOXYNUCLEOTIDES WITH NOVEL MODIFICATIONS - A POSSIBLE APPROACH TO THE PROBLEM OF MIXED BASE OLIGODEOXYNUCLEOTIDE SYNTHESIS [J].

MILLICAN, TA ;

MOCK, GA ;

CHAUNCEY, MA ;

PATEL, TP ;

EATON, MAW ;

GUNNING, J ;

CUTBUSH, SD ;

NEIDLE, S ;

MANN, J .

NUCLEIC ACIDS RESEARCH, 1984, 12 (19) :7435-7453

[7] HOW DO THE GAUCHE AND ANOMERIC EFFECTS DRIVE THE PSEUDOROTATIONAL EQUILIBRIUM OF THE PENTOFURANOSE MOIETY OF NUCLEOSIDES [J].

PLAVEC, J ;

TONG, WM ;

CHATTOPADHYAYA, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (21) :9734-9746

[8] STEREOSELECTIVE REDUCTION OF GLYCOSYL HALIDES BY TRIBUTYLTIN DEUTERIDE [J].

PRALY, JP .

TETRAHEDRON LETTERS, 1983, 24 (30) :3075-3078

[9] SEQUENCE REQUIREMENTS OF THE HAMMERHEAD RNA SELF-CLEAVAGE REACTION [J].

RUFFNER, DE ;

STORMO, GD ;

UHLENBECK, OC .

BIOCHEMISTRY, 1990, 29 (47) :10695-10702

[10] CHEMICAL SYNTHESIS OF BIOLOGICALLY-ACTIVE OLIGORIBONUCLEOTIDES USING BETA-CYANOETHYL PROTECTED RIBONUCLEOSIDE PHOSPHORAMIDITES [J].

SCARINGE, SA ;

FRANCKLYN, C ;

USMAN, N .

NUCLEIC ACIDS RESEARCH, 1990, 18 (18) :5433-5441

← 1 2 →