COFFEE CONSUMPTION AND THE RISK OF CANCER OF THE EXOCRINE PANCREAS - A CASE-CONTROL STUDY IN A LOW-RISK POPULATION

被引：44

作者：

LYON, JL

MAHONEY, AW

FRENCH, TK

MOSER, R

机构：

[1] Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT

[2] Department of Food Science and Nutrition, Utah State University, Logan, UT

来源：

EPIDEMIOLOGY | 1992年 / 3卷 / 02期

关键词：

CASE-CONTROL STUDIES; PANCREATIC NEOPLASMS; COFFEE; CAFFEINE; CIGARETTES; SMOKING; PROXY RESPONDENTS; GENDER;

D O I：

10.1097/00001648-199203000-00015

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Data from a population-based, case-control study of 149 cases of cancer of the exocrine pancreas (excluding insulinomas) and 363 controls were used to test the hypothesis that coffee consumption increased the risk of cancer of the exocrine pancreas. Because of the high mortality from cancer of the pancreas, all information was obtained from proxy respondents for cases and controls. Increased risk was present for coffee drinkers [odds ratio (OR) = 2.38], cigarette smokers (OR = 2.27), and alcohol users (OR = 1.60), but the effect for alcohol disappeared after adjustment for cigarette use. Risk increased with the amount of coffee drunk with an OR of 2.38 in the those having at least 50,000 lifetime cups. This gradient was present in both men and women, and in cigarette smokers and nonsmokers. Increased risk was present for users of regular and decaffeinated coffee, but the risk was higher for users of decaffeinated coffee than users of regular coffee. Cigarette smoking, after controlling for coffee consumption, was an independent risk factor for pancreatic cancer, with odds ratios in the heaviest smokers of 2.71 (95% confidence interval = 1.41-5.21).

引用

页码：164 / 170

页数：7

共 31 条

[1]

Annual Cancer Statistics Review, (1986)

[2]

The Health Consequences of Smoking—Cancer: A Report of the Surgeon General, pp. 21-169, (1982)

[3]

Macmahon B., Yen S., Trichopoulos D., Warren K., Nardi G., Coffee and cancer of the pancreas, N Engl J Med, 304, pp. 630-663, (1981)

[4]

Jick H., Dinan B.J., Coffee and pancreatic cancer (Letter), Lancet, 2, (1981)

[5]

Whittemore A.S., Paffenbarger R.S., Erson K., Halpem J., Early Precursors of Pancreatic Cancer in College Men, J Chron Dis, 36, pp. 251-256, (1983)

[6]

Wynder E.L., Hall N.E.L., Polansky M., Epidemiology of coffee and pancreatic cancer, Cancer Res, 43, pp. 3900-3906, (1983)

[7]

Kinlen L.J., McPherson K., Pancreas cancer and coffee and tea consumption: A case-control study, Br J Cancer, 49, pp. 93-96, (1984)

[8]

Gold E.B., Gordis L., Diener M.D., Seltser R., Boitnott J.K., Bynum T.E., Hutcheon D.F., Diet and other risk factors for cancer of the pancreas, Cancer, 55, pp. 460-467, (1985)

[9]

Jacobsen B.K., Bjelke E., Kvale G., Heuch I., Coffee drinking, mortality, and cancer incidence: Results from a Norwegian prospective study, J Natl Cancer Inst, 76, pp. 823-831, (1986)

[10]

Mack T.M., Yu M.C., Hanisch R., Henderson B.E., Pancreas cancer and smoking, beverage consumption, and past medical history, J Natl Cancer Inst, 76, pp. 49-60, (1986)

← 1 2 3 4 →