EFFECTS OF MPTP ON THE CEREBROVASCULATURE

被引：10

作者：

ADAMS, JD ^{[1
]}

KLAIDMAN, LK ^{[1
]}

ODUNZE, IN ^{[1
]}

JOHANNESSEN, JN ^{[1
]}

机构：

[1] NIH,BETHESDA,MD 20205

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 1991年 / 9卷 / 02期

关键词：

MPTP; BRAIN MICROVASCULATURE; BLOOD BRAIN BARRIER;

D O I：

10.1016/0736-5748(91)90006-8

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, has been shown to cause pooling of blood in the brain microvasculature and decrease the permeability of the blood-brain barrier. All areas of the brain examined in this study were affected. This study points out the possibility that reduced nutrient uptake, hypoxia and ensuing free radical damage are involved in the mechanism of toxicity of this neurotoxin.

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收藏

页码：155 / 159

页数：5

相关论文

共 12 条

[1] INDUCTION BY 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE OF LIPID-PEROXIDATION INVIVO IN VITAMIN-E DEFICIENT MICE [J].

ADAMS, JD ;

ODUNZE, IN ;

SEVANIAN, A .

BIOCHEMICAL PHARMACOLOGY, 1990, 39 (01) :R5-R8

[2]

ADAMS JD, 1989, RES COMMUN SUBSTANCE, V10, P169

[3] THE ACUTE HISTOPATHOLOGY OF MPTP IN THE MOUSE CNS [J].

ADAMS, JD ;

KALIVAS, PW ;

MILLER, CA .

BRAIN RESEARCH BULLETIN, 1989, 23 (1-2) :1-17

[4] BACKGROUND STAINING AND SENSITIVITY OF UNLABELLED ANTIBODY-ENZYME (PAP) METHOD - COMPARISON WITH PEROXIDASE LABELED ANTIBODY SANDWICH METHOD USING FORMALIN FIXED PARAFFIN EMBEDDED MATERIAL [J].

BURNS, J .

HISTOCHEMISTRY, 1975, 43 (03) :291-294

[5]

CHIBA K, 1984, BIOCHEM BIOPH RES CO, V120, P573

[6] INHIBITION OF DOPAMINE UPTAKE BY N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE, A CAUSE OF PARKINSONISM [J].

DENTON, T ;

HOWARD, BD .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 119 (03) :1186-1190

[7] MPTP TOXICITY IN THE MOUSE-BRAIN AND VITAMIN-E [J].

ODUNZE, IN ;

KLAIDMAN, LK ;

ADAMS, JD .

NEUROSCIENCE LETTERS, 1990, 108 (03) :346-349

[8]

OLDENDORF WH, 1981, RES METHODS NEUROCHE, V5, P91

[9] INFLUENCE OF COMPLETE AND PRONOUNCED INCOMPLETE CEREBRAL-ISCHEMIA AND SUBSEQUENT RECIRCULATION ON CORTICAL CONCENTRATIONS OF OXIDIZED AND REDUCED GLUTATHIONE IN THE RAT [J].

REHNCRONA, S ;

FOLBERGROVA, J ;

SMITH, DS ;

SIESJO, BK .

JOURNAL OF NEUROCHEMISTRY, 1980, 34 (03) :477-486

[10] DOPAMINE TURNOVER AND GLUTATHIONE OXIDATION - IMPLICATIONS FOR PARKINSON DISEASE [J].

SPINA, MB ;

COHEN, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (04) :1398-1400