NERVE GROWTH-FACTOR RECEPTOR-LIKE IMMUNOREACTIVITY IN NERVE-FIBERS IN THE SPINAL AND MEDULLARY DORSAL HORN OF THE ADULT MONKEY AND CAT - CORRELATION WITH CALCITONIN GENE-RELATED PEPTIDE-LIKE IMMUNOREACTIVITY

The distribution of nerve growth factor receptor (NGFr)-like immunoreactivity and of calcitonin gene-related peptide (CGRP)-like immunoreactivity was studied in nerve fibers of the spinal and medullary dorsal horn of the monkey and the cat, using double-labelling immunohistochemistry with polyclonal CGRP antiserum and a monoclonal antibody against human NGFr. In both species there was an extensive distribution overlap between NGFr-LI and CGRP-LI. However, lack of NGFr-LI in many CGRP-immunoreactive axons suggests that not all CGRP-positive primary afferent fibers possess NGFr.