LONG-TERM HYPOTENSIVE EFFECT OF PARATHYROID-HORMONE IN STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS

被引：7

作者：

NEUSER, D

SCHULTEBRINKMANN, R

KNORR, A

KAZDA, S

机构：

[1] Bayer AG, Department of Pharmacology, Pharma Research Center, D-5600 Wuppertal 1

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 182卷 / 03期

关键词：

Blood pressure; Hypercalcemia; Parathyroid hormone; Spontaneously hypertensive rats; stroke prone (SHR/SP);

D O I：

10.1016/0014-2999(90)90057-D

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The influence of long-term treatment with parathyroid hormone (PTH) on blood pressure (BP) development in stroke prone spontaneously hypertensive rats (SHR/SP) was investigated. Acute i.v. administration of PTH decreased BP dose dependently. Long-term treatment of SHR/SP with 300 IU PTH s.c. per day clearly attenuated the BP increase. Treatment with PTH was associated with marked hypercalcemia, increased urinary excretion of calcium and cAMP. © 1990.

引用

页码：569 / 571

页数：3