LONG-TERM HYPOTENSIVE EFFECT OF PARATHYROID-HORMONE IN STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS

被引：7
作者：
NEUSER, D
SCHULTEBRINKMANN, R
KNORR, A
KAZDA, S
机构：
[1] Bayer AG, Department of Pharmacology, Pharma Research Center, D-5600 Wuppertal 1
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 182卷 / 03期
关键词：
Blood pressure; Hypercalcemia; Parathyroid hormone; Spontaneously hypertensive rats; stroke prone (SHR/SP);
D O I：
10.1016/0014-2999(90)90057-D
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The influence of long-term treatment with parathyroid hormone (PTH) on blood pressure (BP) development in stroke prone spontaneously hypertensive rats (SHR/SP) was investigated. Acute i.v. administration of PTH decreased BP dose dependently. Long-term treatment of SHR/SP with 300 IU PTH s.c. per day clearly attenuated the BP increase. Treatment with PTH was associated with marked hypercalcemia, increased urinary excretion of calcium and cAMP. © 1990.
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收藏
页码：569 / 571
页数：3
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