OSTEOSARCOMA IN YOUNG-CHILDREN

被引：1

作者：

KOZAKEWICH, H

PEREZATAYDE, AR

GOORIN, AM

WILKINSON, RH

GEBHARDT, MC

VAWTER, GF

机构：

[1] CHILDRENS HOSP MED CTR,DEPT HEMATOL & ONCOL,BOSTON,MA 02115

[2] CHILDRENS HOSP MED CTR,DEPT RADIOL,BOSTON,MA 02115

[3] CHILDRENS HOSP MED CTR,DEPT ORTHOPED SURG,BOSTON,MA 02115

[4] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV PEDIAT ONCOL,BOSTON,MA 02115

[5] HARVARD UNIV,SCH MED,BOSTON,MA 02115

来源：

CANCER | 1991年 / 67卷 / 03期

关键词：

D O I：

10.1002/1097-0142(19910201)67:3<638::AID-CNCR2820670319>3.0.CO;2-T

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The clinicopathologic features of osteosarcoma in 12 children younger than 6 years of age treated at The Children's Hospital and Dana-Farber Cancer Institute, Boston, during a 70-year time period are presented. Only one of six children treated before 1972 is a long-term survivor. Four of six children (67%) treated after 1972 are disease-free with an average follow-up of 8.8 years. The year 1972 marked the onset of use of effective chemotherapy in osteosarcoma, namely, high-dose methotrexate and leucovorin rescue. It would appear that the pathologic features and behavior of osteosarcoma in young children is similar to that of osteosarcoma in older children and adolescents. A combination of complete (wide) surgical resection or amputation and aggressive chemotherapy offers the best chance of long-term survival.

引用

页码：638 / 642

页数：5

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