MAPPING OF INFLUENZA-VIRUS GENOME - IDENTIFICATION OF HEMAGGLUTININ AND NEURAMINIDASE GENES

被引：147

作者：

PALESE, P ^{[1
]}

SCHULMAN, JL ^{[1
]}

机构：

[1] CUNY MT SINAI SCH MED, DEPT MICROBIOL, NEW YORK, NY 10029 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1976年 / 73卷 / 06期

关键词：

D O I：

10.1073/pnas.73.6.2142

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Polyacrylamide gel electrophoresis of the RNA of influenza A/PR/8/34(H0N1) and A/Hong Kong/8/68(H3N2) viruses and recombinant viruses derived from them revealed that each contains 8 RNA segments, the 4th of which codes for hemagglutinin. (The largest RNA of the segmented genome is counted as band 1.) The neuraminidase gene was identified as the 6th segment in the RNA pattern of influenza A/PR8 virus and as the 5th segment of A/Hong Kong virus. The MW''s of the RNAs for the hemagglutinin and the neuraminidase genes lie in the range of 600,000-700,000.

引用

页码：2142 / 2146

页数：5

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