Separation of Radiocopper Cu-64/67 from the Matrix of Neutron-Irradiated Natural Zinc Applicable for Cu-64 Production

被引:2
作者
Soenarjo, S. [1 ]
Sriyono [1 ]
Rahman, W. Y. [1 ]
Sarmini, E. [1 ]
Hambali [1 ]
Triyanto [1 ]
机构
[1] Natl Nucl Energy Agcy, Ctr Radioisotopes & Radiopharmaceut, Serpong 15314, Tangerang, Indonesia
关键词
Radioisotope Cu-64; Nuclear reaction of Zn-64 (n; p); Cu-64; Radionuclidic separation of Cu-64; Neutron irradiation of natural Zn; Molecular-targeted-radiopharmaceutical;
D O I
10.17146/aij.2012.136
中图分类号
TL [原子能技术]; O571 [原子核物理学];
学科分类号
0827 ; 082701 ;
摘要
Radioisotope Cu-64 is a promising radiometallic-isotope for molecular-targeted-radiopharmaceuticals. Having a half-life of 12.70 hours and emitting beta(+)-radiation (E beta+ = 0.6531 MeV) as well as beta(-) ray (E-beta = 0.5787 MeV), it is widely used in the form of biomedical-substrate-radiopharmaceutical for positron emission tomography (PET) diagnosis and simultaneously for targeted radiotherapy of cancer. The potential needs on the availability of Cu-64-labeled pharmaceuticals for domestic nuclear medicine hospitals lead to a necessity for the local production of carrier-free Cu-64 using BATAN's G.A. Siwabessy reactor because of the technical and economical constraints in the production using BATAN's cyclotron. The presented work is accordingly to study whether the radioisotope Cu-64 can be produced and separated from the matrix of post-neutron-irradiated-natural zinc. This study is expected can be further improved and implemented in production technology of carrier-free Cu-64 based on Zn-64 (n, p) Cu-64 nuclear reaction exploiting the fast neutron fraction among the major thermal fraction due to unavailability of fast-neutron-irradiation facility in the BATAN's G. A. Siwabessy reactor. The solution of post-neutron-irradiated-natural zinc in 1M acetic acid was loaded into Chelex-100 cation exchanger resin column to pass out the Zn/Zn* fraction whereas the Cu* fraction which remained in the column was then eluted out from the column by using 1.5 M HCl and loaded into the second column containing Dowex-1X8 anion exchanger resin. The second column was then eluted with 0.5 M HCl. The collected eluate was expected to be zinc-free Cu* fraction. It was observed from the half-life and the.-spectrometric analysis that radioactive copper-Cu-64 containing Cu-67 was produced by neutron activation on the natural Zn-foil target and can be separated from the target matrix by the presented two-steps-column- chromatographic separation technique. The radioactivity measurement showed that wrapping the Zn target with cadmium foil increased the activity of radioactive copper and, thus, the Cu*/Zn*-ratio. (C) 2012 Atom Indonesia. All rights reserved
引用
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页码:15 / 21
页数:7
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