De novo acute myeloid leukemia with monocytoid blasts and erythrophagocytosis

被引：6

作者：

Blieden, Clifford ^{[1
]}

Fan, Yao-Shan ^{[2
]}

Chapman, Jennifer Rose ^{[1
]}

Vega, Francisco ^{[1
]}

机构：

[1] Univ Miami, Sylvester Comprehens Canc Ctr, Dept Pathol & Lab Med, Div Hematopathol, Miami, FL USA

[2] Univ Miami, Sylvester Comprehens Canc Ctr, Dept Cytogenet, Miami, FL USA

来源：

CLINICAL CASE REPORTS | 2014年 / 2卷 / 06期

关键词：

AML with t( 8; 16); CREBBP; erythrophagocytosis; monoblasts; MYST3;

D O I：

10.1002/ccr3.120

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Key Clinical Message Acute myeloid leukemia (AML) with t(8: 16) is an infrequent acute leukemia subtype. It can occur de novo or more frequently therapy-related. The presence of blasts with monocytoid morphology and erythrophagocytosis suggest the presence of the t(8; 16).

引用

页码：333 / 335

页数：3

共 4 条

[1] The translocation t(8;l6)(p11, p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB binding protein [J].

Borrow, J ;

Stanton, VP ;

Andresen, JM ;

Becher, R ;

Behm, FG ;

Chaganti, RSK ;

Civin, CI ;

Disteche, C ;

Dube, I ;

Frischauf, AM ;

Horsman, D ;

Mitelman, F ;

Volinia, S ;

Watmore, AE ;

Housman, DE .

NATURE GENETICS, 1996, 14 (01) :33-41

[2] Acute myeloid leukaemia with 8p11 (MYST3) rearrangement:: an integrated cytologic, cytogenetic and molecular study by the groupe francophone de cytogenetique de hematologique [J].

Gervais, C. ;

Murati, A. ;

Helias, C. ;

Struski, S. ;

Eischen, A. ;

Lippert, E. ;

Tigaud, I. ;

Penther, D. ;

Bastard, C. ;

Mugneret, F. ;

Poppe, B. ;

Speleman, F. ;

Talmant, P. ;

Akker, J. VanDen ;

Baranger, L. ;

Barin, C. ;

Luquet, I. ;

Nadal, N. ;

Nguyen-Khac, F. ;

Maarek, O. ;

Herens, C. ;

Sainty, D. ;

Flandrin, G. ;

Birnbaum, D. ;

Mozziconacci, M-J ;

Lessard, M. .

LEUKEMIA, 2008, 22 (08) :1567-1575

[3] AML with translocation t(8;16)(p11;p13) demonstrates unique cytomorphological, cytogenetic, molecular and prognostic features [J].

Haferlach, T. ;

Kohlmann, A. ;

Klein, H-U ;

Ruckert, C. ;

Dugas, M. ;

Williams, P. M. ;

Kern, W. ;

Schnittger, S. ;

Bacher, U. ;

Loeffler, H. ;

Haferlach, C. .

LEUKEMIA, 2009, 23 (05) :934-943

[4] Type I MOZ/CBP (MYST3/CREBBP) is the most common chimeric transcript in acute myeloid leukemia with t(8;16)(p11;p13) translocation [J].

Rozman, M ;

Camós, M ;

Colomer, D ;

Villamor, N ;

Esteve, J ;

Costa, D ;

Carrió, A ;

Aymerich, M ;

Aguilar, JL ;

Domingo, A ;

Solé, F ;

Gomis, F ;

Florensa, L ;

Montserrat, E ;

Campo, E .

GENES CHROMOSOMES & CANCER, 2004, 40 (02) :140-145

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