Hyaluronan: its potential application in intervertebral disc regeneration

被引：10

作者：

Shen, Bojiang ^{[1
]}

Wei, Aiqun ^{[1
]}

Bhargav, Divya ^{[1
]}

Kishen, Thomas ^{[1
]}

Diwan, Ashish D. ^{[1
]}

机构：

[1] Univ New South Wales, St George Hosp, Dept Orthopaed Surg, Orthopaed Res Inst, Sydney, NSW, Australia

来源：

ORTHOPEDIC RESEARCH AND REVIEWS | 2010年 / 2卷

关键词：

hyaluronan; cartilage; intervertebral disc; stromal cells; tissue engineering; back pain;

D O I：

10.2147/ORR.S7741

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Hyaluronan (HA) is a ubiquitous component of extracellular matrix in human tissues with diverse functions in skeletal biology. The biophysical properties of HA, such as high viscosity, elasticity and highly negative charge, make it useful in various therapeutic procedures. Although intra-articular administration of HA has been extensively used in the management of osteoarthritis (OA), there is a paucity of data on the clinical application of HA in intervertebral disc repair. This review discusses the biology and signaling mechanisms of HA, the pathophysiology of disc degeneration and summarises current evidence relating to the role of HA in cell phenotype maintenance, differentiation of chondrocytes, intervertebral disc cells and bone marrow stromal cells, and its application in tissue engineering. Based on recent advances in the clinical outcomes of OA treatment, HA has demonstrated potential as a bio-polymer filler, therapeutic agent and cell carrier in the management of intervertebral disc degeneration.

引用

页码：17 / 26

页数：10

共 81 条

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