SPONTANEOUS AND GLUCOCORTICOID-INDUCED APOPTOSIS IN HUMAN MATURE T-LYMPHOCYTES

被引:112
作者
BRUNETTI, M
MARTELLI, N
COLASANTE, A
PIANTELLI, M
MUSIANI, P
AIELLO, FB
机构
[1] IST RIC FARMACOL MARIO NEGRI, CONSORZIO MARIO NEGRI SUD, TUMOR & VASC CELL BIOL LAB, I-66030 SANTA MARIA IMBARO, ITALY
[2] UNIV G DANNUNZIO, DEPT HUMAN PATHOL, CHIETI, ITALY
关键词
D O I
10.1182/blood.V86.11.4199.bloodjournal86114199
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Glucocorticoid (GC)-induced apoptosis is a well-recognized physiologic regulator of murine T-cell number and function. We have analyzed its mechanisms in human mature T cells, which have been thought to be insensitive until recently. Peripheral blood T cells showed sensitivity to GC-induced apoptosis soon after the proliferative response to a mitogenic stimulation, and were also sensitive to spontaneous tie, growth factor deprivation-dependent) apoptosis. CD8(+) T cells were more sensitive to both forms than CD4(+) T cells. Acquisition of sensitivity to GC-induced apoptosis was not associated with any change in number or affinity of GC receptors. Both spontaneous and GC-induced apoptosis were increased by the macromolecular synthesis inhibitors, cycloheximide (CHX) and puromycin. A positive correlation between the degree of protein synthesis inhibition and the extent of apoptosis was observed. Interleukin-2 (IL-2) IL-4, and IL-10 protected (IL-2 > IL-10 > IL-4) T cells from both forms of apoptosis in a dose-dependent manner. Our data suggest that spontaneous and GC-induced apoptosis regulate the human mature T-cell repertoire by acting early after the immune response and differentially affecting T-cell subsets. (C) 1995 by The American Society of Hematology.
引用
收藏
页码:4199 / 4205
页数:7
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