THE INFLUENCE OF INDOMETHACIN AND GUANETHIDINE ON EXPERIMENTAL STREPTOZOTOCIN DIABETIC NEUROPATHY

被引：39

作者：

ZOCHODNE, DW ^{[1
]}

HO, LT ^{[1
]}

机构：

[1] QUEENS UNIV, PERIPHERAL NERVE RES LAB, KINGSTON K7L 3N6, ONTARIO, CANADA

来源：

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES | 1992年 / 19卷 / 04期

关键词：

D O I：

10.1017/S0317167100041615

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In diabetic animals. reduced endoneurial perfusion and oxygen content have been linked to neuropathic abnormalities and might be amenable to pharmacological manipulation. In streptozotocin-induced diabetic rats, we studied the influence of guanethidine adrenergic sympathectomy, indomethacin treatment and a combined strategy on: serial in vivo motor and sensory conduction, resistance to ischemic conduction failure, in vitro myelinated and unmyelinated conduction. endoneurial perfusion and endoneurial oxygen tension. Unlike previous work diabetic animals had normal endoneurial perfusion but lower endoneurial oxygen tensions after six months of hyperglycemia. Guanethidine worsened sensory conduction despite lower microvascular resistance and an improvement in endoneurial oxygen tension. In contrast, indomethacin improved motor and sensory conduction but not oxygen tension. These studies do not support a linkage between conduction deficits and early endoneurial microangiopathy in experimental diabetes. Indomethacin, or related agents may offer a new therapeutic approach toward diabetic neuropathy through a mechanism independent of the endoneurial microvasculature.

引用

页码：433 / 441

页数：9

共 46 条

[1]

BAUDOIN C, 1989, DIABETES, V38, P491

[2]

BISCHOFF A, 1967, DTSCH GESELLSCHAFT I, V18, P1138

[3]

BROWNLEE M, 1988, NEW ENGL J MED, V318, P1315

[4]

CAMERON NE, 1990, DIABETIC MED S1, V7, pA2

[5] INHIBITION OF HUMAN LENS ALDOSE REDUCTASE BY FLAVONOIDS, SULINDAC AND INDOMETHACIN [J].

CHAUDHRY, PS ;

CABRERA, J ;

JULIANI, HR ;

VARMA, SD .

BIOCHEMICAL PHARMACOLOGY, 1983, 32 (13) :1995-1998

[6]

DITZEL J, 1976, DIABETES, V25, P832

[7] CAPILLARY NUMBER AND PERCENTAGE CLOSED IN HUMAN DIABETIC SURAL NERVE [J].

DYCK, PJ ;

HANSEN, S ;

KARNES, J ;

OBRIEN, P ;

YASUDA, H ;

WINDEBANK, A ;

ZIMMERMAN, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (08) :2513-2517

[8] THE SPATIAL-DISTRIBUTION OF FIBER LOSS IN DIABETIC POLYNEUROPATHY SUGGESTS ISCHEMIA [J].

DYCK, PJ ;

KARNES, JL ;

OBRIEN, P ;

OKAZAKI, H ;

LAIS, A ;

ENGELSTAD, J .

ANNALS OF NEUROLOGY, 1986, 19 (05) :440-449

[9] HYPOXIC NEUROPATHY - DOES HYPOXIA PLAY A ROLE IN DIABETIC NEUROPATHY - THE 1988 WARTENBERG,ROBERT LECTURE [J].

DYCK, PJ .

NEUROLOGY, 1989, 39 (01) :111-118

[10] FIBER LOSS IS PRIMARY AND MULTIFOCAL IN SURAL NERVES IN DIABETIC POLYNEUROPATHY [J].

DYCK, PJ ;

LAIS, A ;

KARNES, JL ;

OBRIEN, P ;

RIZZA, R .

ANNALS OF NEUROLOGY, 1986, 19 (05) :425-439

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