CLINICAL AND ENDOCRINOLOGIC CHANGES IN WOMEN FOLLOWING OVULATION INDUCTION USING BUSERELIN ACETATE HUMAN MENOPAUSAL GONADOTROPIN AUGMENTED WITH BIOSYNTHETIC HUMAN GROWTH-HORMONE

被引：15
作者：
HUGHES, SM
HUANG, ZH
MATSON, PL
BUCK, P
LIEBERMAN, BA
MORRIS, ID
机构：
[1] Regional IVF Unit, St Mary's Hospital, Manchester M13 OJH, Whitworth Park
[2] Department of Physiological Sciences, University of Manchester
来源：
HUMAN REPRODUCTION | 1992年 / 7卷 / 06期
关键词：
GROWTH HORMONE; INVITRO FERTILIZATION; INHIBIN; INSULIN-LIKE GROWTH FACTORS; OVARIAN STIMULATION;
D O I：
10.1093/oxfordjournals.humrep.a137735
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Biosynthetic human growth hormone added to an ovarian stimulation regime of human menopausal gonadotrophin (HMG) for IVF treatment improves the response of women who were previously resistant. This study investigated the efficacy of growth hormone (GH)/buserelin/HMG treatment in women with a previous normal response to buserelin/HMG stimulation. Ten patients (28-36 years, mean 32.5 years) were treated with GH (6 IU/day) plus buserelin/HMG. A control group of 10 women (28-37 years mean 31.0 years) received buserelin/HMG alone. All were given buserelin 500-mu-g and 2 ampoules (150 IU) HMG daily once pituitary suppression had been confirmed. There was no improvement in the GH group as assessed by follicular growth rate or number, oocyte number per woman and pregnancy rate. There was no effect of GH upon the serum oestradiol level and the follicular fluid levels of oestradiol, GH and inhibin. Serum IGF-1 increased significantly during GH administration, returning to pre-treatment levels 2 days after the last dose of GH. Follicular IGF-I was much higher in the GH-treated group than the controls. Significant correlations were found in the GH-treated group between follicular fluid GH and follicular fluid oestradiol concentrations and between follicular GH and follicular size. Follicular IGF-1 was correlated with the serum IGF-1 concentration on day 8 of the GH/HMG treatment. In conclusion GH/buserelin/HMG treatment in women with a previous normal response to buserelin/HMG stimulation increased their serum and follicular IGF-1 concentrations. However, it does not improve the clinical ovarian response or the follicular secretion of oestradiol or inhibin.
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页码：770 / 775
页数：6
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