A COMPARISON OF 5-HYDROXYINDOLES IN VARIOUS REGIONS OF DOG BRAIN AND CEREBROSPINAL FLUID

被引：107

作者：

ECCLESTON, D

ASHCROFT, GW

MOIR, ATB

PARKERRH.A

LUTZ, W

OMAHONEY, DP

机构：

[1] M.R.C. Unit for Research in Brain Metabolism, Department of Pharmacology, University of Edinburgh

来源：

JOURNAL OF NEUROCHEMISTRY | 1968年 / 15卷 / 09期

关键词：

D O I：

10.1111/j.1471-4159.1968.tb11637.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract— —Normal values for the concentration of 5‐HT, 5‐HIAA and tryptophan are established in various regions of the dog brain. After administration of tryptophan by intravenous injection the rise and fall of 5‐HT and 5‐HIAA were estimated at 1, 2 and 4 hr. Best fit quadratic regression curves obtained by computer programme were fitted to the data. Similar tryptophan doses were given to dogs and the 5‐HIAA concentration estimated in the cisternal CSF. Quadratic regression curves fitted to these values show that the concentration of 5‐HIAA in CSF reflects the changes of 5‐HIAA in the brain and in particular in the brain stem. a‐Methyl dopa pretreatment blocked the rise of 5‐hydroxyindoles in brain and CSF and appeared to inhibit tryptophan hydroxylase as well as decarboxylase. Copyright © 1968, Wiley Blackwell. All rights reserved

引用

页码：947 / +

页数：1

共 18 条

[1] THE DISTRIBUTION OF SUBSTANCE-P AND 5-HYDROXYTRYPTAMINE IN THE CENTRAL NERVOUS SYSTEM OF THE DOG [J].