Glomerulocystic Kidney Disease and Hepatoblastoma in an Infant: A Rare Presentation

Glomerulocystic kidney disease (GCKD) is a rare condition comprising heritable and nonheritable types [Oh et al.: Nephron 1986; 43: 299-302]. Hepatoblastoma is a sporadically occurring tumor of embryonal origin that is associated with overgrowth syndrome and renal cysts. A concurrent presentation of GCKD with hepatoblastoma was first described in 1989 [Rao et al.: Jpn J Surg 1989; 19: 583-585]. We report the simultaneous presentation of hepatoblastoma and GCKD in a 5-month-old child and explore the probability of insulin-like growth factors, insulin-like growth factor-binding protein and Beckwith-Wiedemann gene mutation as a putative cause. (C) 2015 S. Karger AG, Basel