TYPE-I COLLAGEN GENE-REGULATION AND THE MOLECULAR PATHOGENESIS OF CIRRHOSIS

被引：38
作者：
BRENNER, DA
WESTWICK, J
BREINDL, M
机构：
[1] UNIV CALIF SAN DIEGO, DEPT MED, LA JOLLA, CA 92093 USA
[2] UNIV CALIF SAN DIEGO, PROGRAM MOLEC PATHOL, LA JOLLA, CA 92093 USA
[3] VET AFFAIRS, LA JOLLA, CA 92903 USA
来源：
AMERICAN JOURNAL OF PHYSIOLOGY | 1993年 / 264卷 / 04期
关键词：
COLLAGEN ALPHA-1(I) AND ALPHA-2(I) GENES; CIRRHOSIS;
D O I：
10.1152/ajpgi.1993.264.4.G589
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Cirrhosis is characterized by an increased deposition of extracellular matrix proteins, including type I collagen. Type I collagen is a product of two genes, alpha1(I) and alpha2(I), which are generally coordinately regulated. Since expression of type I collagen genes is increased during cirrhosis, understanding the structure and function of the regulatory components of the type I collagen genes should provide insight into the molecular pathogenesis of cirrhosis. This review will analyze the collagen alpha1(I) gene with respect to chromatin structure, DNA methylation, regulation by agonists, and DNA-protein interactions.
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页码：G589 / G595
页数：7
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