CLEARANCE OF INDOMETHACIN OCCURS PREDOMINANTLY BY RENAL GLUCURONIDATION

被引：9
作者：
MOOLENAAR, F
CRANCRINUS, S
VISSER, J
DEZEEUW, D
MEIJER, DKF
机构：
[1] PHARM HUIS LANDE,2283 VJ RIJSWIJK,NETHERLANDS
[2] UNIV HOSP GRONINGEN,DEPT NEPHROL,9600 RB GRONINGEN,NETHERLANDS
来源：
PHARMACEUTISCH WEEKBLAD-SCIENTIFIC EDITION | 1992年 / 14卷 / 04期
关键词：
CLEARANCE; METABOLIC; RENAL; GLUCURONATES; INDOMETHACIN; PHARMACOKINETICS;
D O I：
10.1007/BF01962537
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this report we describe the conditions of collection, storage and handling of urine samples, collected after oral dosing with indometacin in man, in order to maintain the integrity of the labile glucuronide formed. We found that the body clearance occurs predominantly by renal metabolism, due to glucuronidation in the human kidney. These glucuronides may be converted to isomeric glucuronides and/or the parent compound indometacin during the residence time in the bladder.
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收藏
页码：191 / 195
页数：5
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