L-ARGININE INDUCES RELAXATION OF SMALL MESENTERIC-ARTERIES FROM ENDOTOXIN-TREATED RATS

被引:36
|
作者
SCHNEIDER, F
SCHOTT, C
STOCLET, JC
JULOUSCHAEFFER, G
机构
[1] UNIV LOUIS PASTEUR,PHARMACOL CELLULAIRE & MOLEC LAB,CNRS,URA 0600,BP 24,F-67401 ILLKIRCH GRAFFENS,FRANCE
[2] CTR HOSP REG & UNIV,HOP HAUTPIERRE,SERV REANIMAT MED,F-67098 STRASBOURG,FRANCE
关键词
SHOCK; ENDOTOXIN; NITRIC OXIDE (NO); MESENTERIC ARTERIES (SMALL);
D O I
10.1016/0014-2999(92)90539-G
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effect of arginine (Arg) was studied on norepinephrine- (1-mu-M) precontracted small mesenteric arteries removed from rats treated with E. coli lipopolysaccharide (LPS). The addition of L- (but not D-) Arg (1 mM) relaxed, within 3 min, the small mesenteric arteries from LPS-treated but not from control rats, the maximal relaxation (65.3 +/- 11%) being reached with less than 100-mu-M L-Arg. N(G)-Nitro-L-arginine methyl ester (1 mM) and methylene blue (10-mu-M) restored contractions to the level reached before addition of L-Arg. These results show that LPS induces the production of an L-Arg-derived, nitric oxide-like, relaxing factor in small mesenteric arteries.
引用
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页码:269 / 272
页数:4
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