AMIDE-OXIMES AND BENZODIOXANIC HYDROXIMATES - SYNTHESIS OF NEW COMPOUNDS AND NEUROPSYCHOPHARMACOLOGICAL STUDY

被引：5

作者：

DAVRINCHE, C ^{[1
]}

NGUYENTRIXUONG, E ^{[1
]}

ELHAMAD, Y ^{[1
]}

REYNAUD, P ^{[1
]}

RINJARD, P ^{[1
]}

TRAN, G ^{[1
]}

机构：

[1] COOPERAT PHARMACEUT FRANCAISE,MERAM LABS,F-77020 MELUN,FRANCE

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1992年 / 27卷 / 08期

关键词：

BENZODIOXANE; AMIDE-OXIME; HYDROXIMATE; ANTIDEPRESSANT; NEUROLEPTIC;

D O I：

10.1016/0223-5234(92)90111-D

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The authors describe the O(N)-(dialkylaminoalkyl) amide-oximes, benzodioxanic hydroximates and also the acetylated derivatives of the former compounds (I) which are detoxified. The hydroximates are obtained without structural ambiguity from thiono-esters. Pharmacological testing via the main methods shows that some of these new compounds possess imipraminic, and others neuroleptic properties.

引用

页码：765 / 778

页数：14

共 38 条

[1]

BENKERT VB, 1975, DRUG RES, V25, P1404

[2]

BERNHART G, 1976, EUR J MED CHEM, V11, P369

[3] A NEW METHOD FOR RAPID SCREENING OF MINOR TRANQUILLIZERS IN MICE [J].

BOISSIER, JR ;

SIMON, P ;

ARON, C .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1968, 4 (02) :145-+

[4]

BONNETT R, 1970, CHEM CARBON NITROGEN, P598

[5]

BOURIN M, 1983, ANTIDEPRESSEURS

[6] The isomerism of the oximes part XXXV the amidoximes [J].

Brady, OL ;

Peakin, FH .

JOURNAL OF THE CHEMICAL SOCIETY, 1929, :2267-2271

[7]

BRION JD, 1977, THESIS PARIS 6

[8]

BRION JD, 1983, SYNTHESIS-STUTTGART, V3, P220

[9] ALPHA-ADRENORECEPTOR REAGENTS .1. SYNTHESIS OF SOME 1,4-BENZODIOXANS AS SELECTIVE PRE-SYNAPTIC ALPHA-2-ADRENORECEPTOR ANTAGONISTS AND POTENTIAL ANTI-DEPRESSANTS [J].

CHAPLEO, CB ;

MYERS, PL ;

BUTLER, RCM ;

DOXEY, JC ;

ROACH, AG ;

SMITH, CFC .

JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (06) :823-831

[10] N-15 NMR-STUDIES OF 2-HYDROXYGUANIDINES AND AMIDE OXIMES [J].

CLEMENT, B ;

KAMPCHEN, T .

CHEMISCHE BERICHTE-RECUEIL, 1985, 118 (09) :3481-3491

← 1 2 3 4 →