STUDIES ON ANNELATED 1,4-BENZOTHIAZINES AND 1,5-BENZOTHIAZEPINES .7. SYNTHESIS AND INHIBITION OF BENZODIAZEPINE RECEPTOR-BINDING OF SOME 4,5-DIHYDRO-TETRAZOLO[5,1-D]-1,5-BENZOTHIAZEPINES AND 5-PHENYL-S-TRIAZOLO[3,4-D]-1,5-BENZOTHIAZEPINES

The 4,5-dihydro-tetrazolo[5, 1-d]-1,5-benzothiazepines 3a-k and the 5-phenyl-s-triazolo[3,4-d]-1,5-benzothiazepines 6a-f and 11a-c have been prepared and tested for their ability to displace [H-3] flunitrazepam binding from bovine brain membranes. Some of the triazoloderivatives showed moderate binding affinity for the benzodiazepine receptor.