EHRLICH TUMOR-CELLS - CA2+-UPTAKE MODIFICATION BY ALUMINUM LACTATE

Aluminium lactate provokes the same modification of Ca-45(2+)-Uptake by Ehrlich ascites tumour cells as does ferric lactate. The increase of uptake is metal-complex concentration-dependent, and in contrast to ferric lactate, is only partially inhibited by albumin. Under the same experimental conditions, chromic lactate provoked no modification of that uptake. A plasma membrane rigidity increase provoked by coordination binding of aluminium to phospholipids is likely to be the main cause of Ca2+-uptake modification by aluminium lactate.