AN IMPROVED SYNTHETIC PROCEDURE FOR THE PREPARATION OF PT-195M LABELED ANTITUMOR COMPLEXES

被引：7
作者：
JACKSON, H
MCAULIFFE, CA
PERERA, A
SHARMA, HL
TINKER, NJ
机构：
[1] UNIV MANCHESTER,INST SCI & TECHNOL,DEPT CHEM,MANCHESTER M60 1QD,LANCS,ENGLAND
[2] UNIV MANCHESTER,DEPT MED BIOPHYS,MANCHESTER M13 9PT,LANCS,ENGLAND
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1991年 / 29卷 / 10期
关键词：
PLATINUM; 195MPT; ANTITUMOR; CISPLATIN; CARBOPLATIN; IPROPLATIN;
D O I：
10.1002/jlcr.2580291004
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
An improved synthetic procedure for the preparation of high specific activity Pt-195m labelled cisplatin, carboplatin and iproplatin is reported. The procedure involves synthetic strategies which optimise the yields at each stage of the synthesis, giving products of high purity and in high yield (ie. cisplatin and and carboplatin, 43%, and iproplatin, 22%). A new procedure for the synthesis of carboplatin using silver 1,1-cyclobutanedicarboxylate is also reported.
引用
收藏
页码：1121 / 1130
页数：10
相关论文
共 13 条
  • [1] MICROSCALE SYNTHESES OF ANTI-TUMOR PLATINUM COMPOUNDS LABELED WITH PT-191
    BAER, J
    HARRISON, R
    MCAULIFFE, CA
    ZAKI, A
    SHARMA, HL
    SMITH, AG
    [J]. INTERNATIONAL JOURNAL OF APPLIED RADIATION AND ISOTOPES, 1985, 36 (03): : 181 - 184
  • [2] DESIMONE PA, 1979, CANCER TREAT REP, V63, P951
  • [3] GILE JD, 1951, J CHEM PHYS, V19, P1426
  • [4] EQUILIBRIUM BETWEEN PLATINUM (O) PLATINUM (2) AND PLATINUM (4) IN A CHLORIDE ION MEDIUM AT 60 DEGREES C
    GINSTRUP, O
    LEDEN, I
    [J]. ACTA CHEMICA SCANDINAVICA, 1967, 21 (10): : 2689 - &
  • [5] Hartley FR, 1973, CHEM PLATINUM PALLAD
  • [6] HOBSON C, 1985, THESIS U MANCHESTER
  • [7] HOESCHELE JD, 1982, RADIOCHIM ACTA, V31, P27
  • [8] HOESCHELE JD, 1984, PLATINUM COORDINATIO, P103
  • [9] PERA MF, 1977, CLIN CHEM, V23, P1245
  • [10] RILEY CM, 1984, PHARM INT, P15
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