ISOLATION AND FUNCTIONAL EXPRESSION OF THE HUMAN ATRIAL-NATRIURETIC-PEPTIDE CLEARANCE RECEPTOR CDNA

被引：102
作者：
PORTER, JG
ARFSTEN, A
FULLER, F
MILLER, JA
GREGORY, LC
LEWICKI, JA
机构：
[1] California Biotechnology Inc., Mountain View, CA 94043
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 171卷 / 02期
关键词：
D O I：
10.1016/0006-291X(90)91216-F
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The amino acid sequence of the human atrial natriuretic peptide clearance receptor (ANP C-receptor) was deduced from the nucleotide sequence of cDNA clones obtained from human placental and kidney cDNA libraries. The human sequence is highly homologous to the bovine C-receptor sequence already described, and the corresponding mRNA is expressed in human placenta, adult and fetal kidney and fetal heart. Upon transfection of this cDNA into mammalian cells, recombinant expression experiments revealed that the human ANP C-receptor has a high affinity for ANP (6×10-9 M), similar to that observed for the receptor in other species. These data indicate that the human ANP C-receptor, previously characterized in other mammalian species, is highly conserved structurally and is expressed in various human tissues. © 1990.
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收藏
页码：796 / 803
页数：8
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