A COMPARATIVE STUDY OF ABO BLOOD GROUPS AND SECRETOR STATUS IN ISCHAEMIC HEART DISEASE PATIENTS IN KADAPA CITY

BACKGROUND Obesity, hypertension, diabetes mellitus, dyslipidaemia, smoking, stress, sedentary lifestyle and genetic factors are some well- known risk factors for Ischaemic Heart Disease (IHD). The ABO blood groups and secretor status may be linked to IHD and its risk factors. Aim- To study the correlation between ABO blood groups and secretor status in the IHD patients in the city of Kadapa. MATERIALS AND METHODS This study was conducted in Department of Physiology, RIMS Medical College, from August 2015 to January 2016. This is a case control study and selection of cases and controls was done by simple random sampling. 600 patients with IHD diagnosed based on the electrocardiograms were chosen from Cardiology Unit, RIMS General Hospital, Kadapa. 600 volunteer blood donor's age and sex matched with no evidence of any disease were included. Blood group estimation was done by slide agglutination method and secretor status was done by indirect haemagglutination method. The sample size required was taken for convenience. Chi-square test and p-value were used for statistical analysis by SPSS Software version 17. RESULTS The frequency distribution among IHD patients was maximum in B group (45.6 %) followed by 0 group (21.6%), A group (19.9%) and AB group (12.7%). Among the cases, 21.5% were secretors and 78.5% were non-secretors and there was a significant association of non-secretors with IHD with Chi-square value of 401.3 and a p-value of 0.00000. CONCLUSION The results of this study conclude that B group non-secretors are more prone to IHD in the city of Kadapa.