STUDIES ON THE PREPARATION, CHARACTERIZATION AND SOLUBILITY OF B-CYCLODEXTRIN-NELFINAVIR INCLUSION COMPLEXES

被引：0

作者：

Hiremath, S. N. ^{[1
]}

Godge, G. R. ^{[2
]}

Kharia, A. A. ^{[3
]}

Vaidya, V. R. ^{[4
]}

机构：

[1] PRESS Coll Pharm, Nasik 422101, India

[2] PDVVPFS Coll Pharm, Vilad Ghat 414111, Ahmednagar, India

[3] Oriental Coll Pharm, Bhopal 462021, India

[4] Padm Dr DY Patil Coll Pharm, Pune 411044, Maharashtra, India

来源：

ASIAN JOURNAL OF PHARMACEUTICAL RESEARCH AND HEALTH CARE | 2010年 / 2卷 / 03期

关键词：

beta-cyclodextrin; physical mixture Kneading Method; coprecipitation & common solvent method;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nelfinavir is a poor water-soluble antiretroviral drug with relatively low bioavailability. The effect of beta-cyclodextrin on the aqueous solubility and dissolution rate of nelfinavir was investigated. Phase solubility studies indicated that the solubility of nelfinavir was significantly enhanced by complexing it with beta-cyclodextrin. It was classified as Bs type indicating the 1:2 stoichiometric inclusion complexes. The various solid complexes prepared by physical mixture, Kneading, coprecipitation & common solvent methods were characterized by DSC, X-RD & FT-IR. Dissolution study showed that the solubility and dissolution rate of nelfinavir was significantly improved by complexation with beta-cyclodextrin.

引用

页码：279 / 284

页数：6

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