Treatment strategies for patients with diffuse large B-cell lymphoma: past, present, and future

被引：14

作者：

Sinha, Rajni ^{[1
]}

Nastoupil, Loretta J. ^{[2
]}

Flowers, Christopher R. ^{[1
]}

机构：

[1] Emory Univ, Winship Canc Inst, Dept Hematol Med Oncol, Atlanta, GA 30322 USA

[2] Emory Univ, Dept Hematol & Oncol, Atlanta, GA 30322 USA

来源：

BLOOD AND LYMPHATIC CANCER-TARGETS AND THERAPY | 2012年 / 2卷

关键词：

non-Hodgkin's lymphoma; diffuse large B-cell lymphoma; lymphoma; chemoimmunotherapy; rituximab; treatment;

D O I：

10.2147/BLCTT.S18701

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Diffuse large B-cell lymphoma (DLBCL) is the most commonly occurring lymphoma in the Western world. DLBCLs are clinically, biologically, and pathologically heterogeneous with biologically distinct subtypes that have different expected treatment outcomes. The -addition of rituximab to combination chemotherapy has improved outcomes for all patients with DLBCL and can cure the disease in certain individuals. Relapsed DLBCL is generally managed with salvage chemoimmunotherapy followed by high-dose therapy and autologous stem cell transplantation, which can cure additional patients. However, outcomes for patients who relapse early after upfront rituximab and chemotherapy are poor. Novel therapies and -strategies are desperately needed for these patients and several emerging treatments hold promise for -improving DLBCL treatment outcomes.

引用

页码：87 / 98

页数：12

共 77 条

[1] Incidence and outcomes of the peripheral T-cell lymphoma subtypes in the United States [J].

Abouyabis, Abeer N. ;

Shenoy, Pareen J. ;

Lechowicz, Mary Jo ;

Flowers, Christopher R. .

LEUKEMIA & LYMPHOMA, 2008, 49 (11) :2099-2107

[2] Prognostic significance of immunohistochemical classification of diffuse large B-cell lymphoma [J].

Alacacioglu, Inci ;

Ozcan, Mehmet Ali ;

Ozkal, Sermin ;

Piskin, Ozden ;

Turgut, Nurhilal ;

Demirkan, Fatih ;

Ozsan, Guner Hayri ;

Kargi, Aydanur ;

Undar, Bulent .

HEMATOLOGY, 2009, 14 (02) :84-89

[3] Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].

Alizadeh, AA ;

Eisen, MB ;

Davis, RE ;

Ma, C ;

Lossos, IS ;

Rosenwald, A ;

Boldrick, JG ;

Sabet, H ;

Tran, T ;

Yu, X ;

Powell, JI ;

Yang, LM ;

Marti, GE ;

Moore, T ;

Hudson, J ;

Lu, LS ;

Lewis, DB ;

Tibshirani, R ;

Sherlock, G ;

Chan, WC ;

Greiner, TC ;

Weisenburger, DD ;

Armitage, JO ;

Warnke, R ;

Levy, R ;

Wilson, W ;

Grever, MR ;

Byrd, JC ;

Botstein, D ;

Brown, PO ;

Staudt, LM .

NATURE, 2000, 403 (6769) :503-511

[4] Second cancers and late toxicities after treatment of aggressive non-Hodgkin lymphoma with the ACVBP regimen:: a GELA cohort study on 2837 patients [J].

André, M ;

Mounier, N ;

Leleu, X ;

Sonet, A ;

Brice, P ;

Henry-Amar, M ;

Tilly, H ;

Coiffier, B ;

Bosly, A ;

Morel, P ;

Haioun, C ;

Gaulard, P ;

Reyes, F ;

Gisselbrecht, C .

BLOOD, 2004, 103 (04) :1222-1228

[5]

[Anonymous], 2009, HEMATOL AM SOC HEMAT

[6] CHOP alone compared with CHOP plus radiotherapy for localized aggressive lymphoma in elderly patients:: A study by the Groupe d'Etude des Lymphomes de I'Adulte [J].

Bonnet, Christophe ;

Fillet, Georges ;

Mounier, Nicolas ;

Ganem, Gard ;

Molina, Thierry Jo ;

Thieblemont, Catherine ;

Ferme, Christophe ;

Quesnel, Bruno ;

Martin, Claude ;

Gisselbrecht, Christian ;

Tilly, Herve ;

Reyes, Felix .

JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (07) :787-792

[7] EXCESS PREVALENCE OF PNEUMOCYSTIS-CARINII PNEUMONIA IN PATIENTS TREATED FOR LYMPHOMA WITH COMBINATION CHEMOTHERAPY [J].

BROWNE, MJ ;

HUBBARD, SM ;

LONGO, DL ;

FISHER, R ;

WESLEY, R ;

IHDE, DC ;

YOUNG, RC ;

PIZZO, PA .

ANNALS OF INTERNAL MEDICINE, 1986, 104 (03) :338-344

[8] From the bench to the bedside: ways to improve rituximab efficacy [J].

Cartron, G ;

Watier, H ;

Golay, J ;

Solal-Celigny, P .

BLOOD, 2004, 104 (09) :2635-2642

[9]

Castillo JJ, 2012, LEUK RES

[10] CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. [J].

Coiffier, B ;

Lepage, E ;

Brière, J ;

Herbrecht, R ;

Tilly, H ;

Bouabdallah, R ;

Morel, P ;

Van den Neste, E ;

Salles, G ;

Gaulard, P ;

Reyes, F ;

Gisselbrecht, C .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (04) :235-242

← 1 2 3 4 5 6 7 8 →