Facing acid-base disorders in the third millennium - the Stewart approach revisited

被引:22
作者
Kishen, R. [1 ,2 ]
Honore, Patrick M. [3 ]
Jacobs, R. [3 ]
Joannes-Boyau, O. [4 ]
De Waele, E. [3 ]
De Regt, J. [3 ]
Van Gorp, V. [3 ]
Boer, W. [5 ]
Spapen, H. D. [3 ]
机构
[1] Salford Royal Hosp NHS Trust, Intens Care Unit, Manchester, Lancs, England
[2] Univ Manchester, Translat Med & Neurosci, Manchester, Lancs, England
[3] Vrije Univ Brussel, Univ Ziekenhuis Brussel, Intens Care Dept, Brussels, Belgium
[4] Univ Bordeaux 2, Haut Leveque Univ, Hosp Bordeaux, Pessac, France
[5] East Limburg Hosp, Intens Care Dept, Genk, Belgium
关键词
hemofiltration; strong ion difference; strong ion gap; dialysis; CRRT; sepsis; bedside acid-base approach; Stewart acid base approach;
D O I
10.2147/IJNRD.S62126
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Acid-base disorders are common in the critically ill. Most of these disorders do not cause harm and are self-limiting after appropriate resuscitation and management. Unfortunately, clinicians tend to think about an acid-base disturbance as a "disease" and spend long hours effectively treating numbers rather than the patient. Moreover, a sizable number of intensive-care physicians experience difficulties in interpreting the significance of or understanding the etiology of certain forms of acid-base disequilibria. Traditional tools for interpreting acid-base disorders may not be adequate for analyzing the complex nature of these metabolic abnormalities. Inappropriate interpretation may also lead to wrong clinical conclusions and incorrectly influence clinical management (eg, bicarbonate therapy for metabolic acidosis in different clinical situations). The Stewart approach, based on physicochemical principles, is a robust physiological concept that can facilitate the interpretation and analysis of simple, mixed, and complex acid-base disorders, thereby allowing better diagnosis of the cause of the disturbance and more timely treatment. However, as the concept does not attach importance to plasma bicarbonate, clinicians may find it complicated to use in their daily clinical practice. This article reviews various approaches to interpreting acid-base disorders and suggests the integration of base-excess and Stewart approach for a better interpretation of these metabolic disorders.
引用
收藏
页码:209 / 217
页数:9
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