NANOSCALE COMPLEXITY OF PHOSPHOLIPID MONOLAYERS INVESTIGATED BY NEAR-FIELD SCANNING OPTICAL MICROSCOPY

被引：127

作者：

HWANG, J

TAMM, LK

BOHM, C

RAMALINGAM, TS

BETZIG, E

EDIDIN, M

机构：

[1] JOHNS HOPKINS UNIV, DEPT BIOL, BALTIMORE, MD 21218 USA

[2] UNIV VIRGINIA, DEPT MOLEC PHYSIOL & BIOL PHYS, CHARLOTTESVILLE, VA 22908 USA

[3] AT&T BELL LABS, MURRAY HILL, NJ 07974 USA

来源：

SCIENCE | 1995年 / 270卷 / 5236期

关键词：

D O I：

10.1126/science.270.5236.610

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Near-field scanning optical microscopy of phospholipid monolayers doped with fluorescent lipid analogs reveals previously undescribed features in various phases, including a concentration gradient at the liquid-expanded/liquid-condensed domain boundary and weblike structures in the solid-condensed phase. Presumably, the web structures are grain boundaries between crystalline solid lipid. These structures are strongly modulated by the addition of low concentrations of cholesterol and ganglioside G(M1) in the monolayer.

引用

页码：610 / 614

页数：5

共 27 条

[1] NEAR-FIELD OPTICS - MICROSCOPY, SPECTROSCOPY, AND SURFACE MODIFICATION BEYOND THE DIFFRACTION LIMIT [J].