DETERMINATION OF RISPERIDONE AND 9-HYDROXYRISPERIDONE IN HUMAN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION

被引：57
|
作者：
LEMOING, JP
EDOUARD, S
LEVRON, JC
机构：
[1] Janssen Research Foundation, Laboratoires Janssen
来源：
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1993年 / 614卷 / 02期
关键词：
D O I：
10.1016/0378-4347(93)80327-Z
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A method for the determination of risperidone and its active metabolite 9-hydroxyrisperidone in human plasma has been developed. The procedure involved a multi-step liquid-liquid extraction with an internal standard. The parent drug and its metabolite were separated on a cyano column used in the reversed-phase model. The coulometric detection allows quantification in the range 2-100 ng/ml. The precision, accuracy and specificity have been checked, and show that the method is reliable for clinical studies.
引用
收藏
页码：333 / 339
页数：7
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