DETERMINATION OF RISPERIDONE AND 9-HYDROXYRISPERIDONE IN HUMAN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION

被引：59

作者：

LEMOING, JP

EDOUARD, S

LEVRON, JC

机构：

[1] Janssen Research Foundation, Laboratoires Janssen

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1993年 / 614卷 / 02期

关键词：

D O I：

10.1016/0378-4347(93)80327-Z

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A method for the determination of risperidone and its active metabolite 9-hydroxyrisperidone in human plasma has been developed. The procedure involved a multi-step liquid-liquid extraction with an internal standard. The parent drug and its metabolite were separated on a cyano column used in the reversed-phase model. The coulometric detection allows quantification in the range 2-100 ng/ml. The precision, accuracy and specificity have been checked, and show that the method is reliable for clinical studies.

引用

页码：333 / 339

页数：7

共 8 条

[1] AN IMPROVED SENSITIVE ASSAY FOR SIMULTANEOUS DETERMINATION OF PLASMA HALOPERIDOL AND REDUCED HALOPERIDOL LEVELS BY LIQUID-CHROMATOGRAPHY USING A COULOMETRIC DETECTOR [J].

HARIHARAN, M ;

KINDT, EK ;

VANNOORD, T ;

TANDON, R .

THERAPEUTIC DRUG MONITORING, 1989, 11 (06) :701-707

[2]

JANSSEN PAJ, 1988, J PHARMACOL EXP THER, V244, P685

[3]

LEYSEN JE, 1988, J PHARMACOL EXP THER, V247, P661

[4]

MEGENS AAH, 1990, R6476623 JANSS PRECL

[5]

MEULDERMANS W, 1990, MAR BELT M LOUV

[6]

Roose K, 1988, Acta Psychiatr Belg, V88, P233

[7] DETERMINATION OF RISPERIDONE AND 9-HYDROXYRISPERIDONE IN PLASMA, URINE AND ANIMAL-TISSUES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

WOESTENBORGHS, R ;

LORREYNE, W ;

VANROMPAEY, F ;

HEYKANTS, J .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1992, 583 (02) :223-230

[8]

WOESTENBORGHS R, 1990, R6476624 JANSS PRECL

← 1 →