LINKAGE ANALYSES OF 5 CHROMOSOME-4 MARKERS LOCALIZES THE FACIOSCAPULOHUMERAL MUSCULAR-DYSTROPHY (FSHD) GENE TO DISTAL 4Q35

被引：0
|
作者：
WEIFFENBACH, B
BAGLEY, R
FALLS, K
HYSER, C
STORVICK, D
JACOBSEN, SJ
SCHULTZ, P
MENDELL, J
VANDIJK, KW
MILNER, ECB
GRIGGS, R
机构：
[1] UNIV ROCHESTER,DEPT NEUROL,ROCHESTER,NY 14627
[2] UNIV CALIF SAN DIEGO,DEPT PEDIAT,LA JOLLA,CA 92093
[3] UNIV CALIF SAN DIEGO,FAC NEUROSCI,LA JOLLA,CA 92093
[4] OHIO STATE UNIV,DEPT NEUROL,COLUMBUS,OH 43210
[5] VIRGINIA MASON RES CTR,SEATTLE,WA 98101
来源：
AMERICAN JOURNAL OF HUMAN GENETICS | 1992年 / 51卷 / 02期
关键词：
D O I：
暂无
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The genetic locus for facioscapulohumeral muscular dystrophy (FSHD) has been mapped to chromosome 4. We have examined linkage to five chromosome 4q DNA markers in 22 multigenerational FSHD families. Multipoint linkage analyses of the segregation of four markers in the FSHD families and in 40 multigenerational mapping families from the Centre d'Etude du Polymorphisme Humaine enabled these loci and FSHD to be placed in the following order: cen-D4S171-factor XI-D4S163-D4S139-FSHD-qter. One interval, D4S171-FSHD, showed significant sex-specific differences in recombination. Homogeneity tests supported linkage of FSHD to these 4q DNA markers in all of the families we studied. The position of FSHD is consistent with that generated by other groups as members of an international FSHD consortium.
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页码：416 / 423
页数：8
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