HIPPOCAMPAL MOSSY FIBER ZINC DEFICIT IN MICE GENETICALLY SELECTED FOR ETHANOL WITHDRAWAL SEIZURE SUSCEPTIBILITY

被引：20

作者：

FELLER, DJ ^{[1
]}

TSOOLIVAS, DY ^{[1
]}

SAVAGE, DD ^{[1
]}

机构：

[1] UNIV NEW MEXICO,SCH MED,DEPT PHARMACOL,ALBUQUERQUE,NM 87131

来源：

BRAIN RESEARCH | 1991年 / 545卷 / 1-2期

关键词：

HIPPOCAMPAL MOSSY FIBER ZINC; ETHANOL WITHDRAWAL SEIZURE; SELECTED LINE; WITHDRAWAL SEIZURE-PRONE MOUSE; WITHDRAWAL SEIZURE-RESISTANT MOUSE;

D O I：

10.1016/0006-8993(91)91271-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Hippocampal mossy fiber zinc was examined in mice selectively bred for differences in susceptibility to handling-induced convulsions during ethanol withdrawal. The density of mossy fiber zinc in the CA3 stratum lucidum was significantly decreased in the duplicate lines of untreated withdrawal seizure prone (WSP) mice compared to untreated withdrawal seizure resistant (WSR) mice. Mossy fiber zinc densities in randomly bred control lines of mice (WSC) were intermediate to WSP and WSR mice. Serum, whole brain and whole hippocampal zinc were not significantly different between WSP and WSR mice, indicating that the reduction in the chelatable pool of hippocampal mossy fiber zinc was not a consequence of deficits in brain or whole body zinc nutrition. A highly significant correlation between hippocampal mossy fiber zinc density and handling-induced convulsion indices suggests that a reduction in mossy fiber zinc may be one contributing factor in the expression of seizure susceptibility in WSP mice.

引用

页码：73 / 79

页数：7

共 50 条

[21] A QUINOLINE FLUORESCENCE METHOD FOR VISUALIZING AND ASSAYING THE HISTOCHEMICALLY REACTIVE ZINC (BOUTON ZINC) IN THE BRAIN [J].

FREDERICKSON, CJ ;

KASARSKIS, EJ ;

RINGO, D ;

FREDERICKSON, RE .

JOURNAL OF NEUROSCIENCE METHODS, 1987, 20 (02) :91-103

[22] LOSS OF ZINC STAINING FROM HIPPOCAMPAL MOSSY FIBERS DURING KAINIC ACID-INDUCED SEIZURES - A HISTOFLUORESCENCE STUDY [J].

FREDERICKSON, CJ ;

HERNANDEZ, MD ;

GOIK, SA ;

MORTON, JD ;

MCGINTY, JF .

BRAIN RESEARCH, 1988, 446 (02) :383-386

[23]

Friedman HJ, 1980, ALCOHOL TOLERANCE DE, P93

[24]

GENGCHAN Y, 1990, MOL PHARMACOL, V38, P14

[25] STIMULATION-INDUCED UPTAKE AND RELEASE OF ZINC IN HIPPOCAMPAL SLICES [J].

HOWELL, GA ;

WELCH, MG ;

FREDERICKSON, CJ .

NATURE, 1984, 308 (5961) :736-738

[26] THE SELECTIVE-INHIBITION OF HIPPOCAMPAL GLUTAMIC-ACID DECARBOXYLASE IN ZINC-INDUCED EPILEPTIC SEIZURES [J].

ITOH, M ;

EBADI, M .

NEUROCHEMICAL RESEARCH, 1982, 7 (10) :1287-1298

[27]

JOBE PC, 1982, FED PROC, V41, P1272

[28]

KOH JY, 1988, J NEUROSCI, V8, P2164

[29]

KOSOBUD A, 1986, J PHARMACOL EXP THER, V238, P170

[30] UBER DEN TOPOCHEMISCHEN NACHWEIS VON ZINK IM AMMONSHORN VERSCHIEDENER SAUGETIERE [J].

MASKE, H .

NATURWISSENSCHAFTEN, 1955, 42 (14) :424-424

← 1 2 3 4 5 →