HIPPOCAMPAL MOSSY FIBER ZINC DEFICIT IN MICE GENETICALLY SELECTED FOR ETHANOL WITHDRAWAL SEIZURE SUSCEPTIBILITY

被引：20

作者：

FELLER, DJ ^{[1
]}

TSOOLIVAS, DY ^{[1
]}

SAVAGE, DD ^{[1
]}

机构：

[1] UNIV NEW MEXICO,SCH MED,DEPT PHARMACOL,ALBUQUERQUE,NM 87131

来源：

BRAIN RESEARCH | 1991年 / 545卷 / 1-2期

关键词：

HIPPOCAMPAL MOSSY FIBER ZINC; ETHANOL WITHDRAWAL SEIZURE; SELECTED LINE; WITHDRAWAL SEIZURE-PRONE MOUSE; WITHDRAWAL SEIZURE-RESISTANT MOUSE;

D O I：

10.1016/0006-8993(91)91271-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Hippocampal mossy fiber zinc was examined in mice selectively bred for differences in susceptibility to handling-induced convulsions during ethanol withdrawal. The density of mossy fiber zinc in the CA3 stratum lucidum was significantly decreased in the duplicate lines of untreated withdrawal seizure prone (WSP) mice compared to untreated withdrawal seizure resistant (WSR) mice. Mossy fiber zinc densities in randomly bred control lines of mice (WSC) were intermediate to WSP and WSR mice. Serum, whole brain and whole hippocampal zinc were not significantly different between WSP and WSR mice, indicating that the reduction in the chelatable pool of hippocampal mossy fiber zinc was not a consequence of deficits in brain or whole body zinc nutrition. A highly significant correlation between hippocampal mossy fiber zinc density and handling-induced convulsion indices suggests that a reduction in mossy fiber zinc may be one contributing factor in the expression of seizure susceptibility in WSP mice.

引用

页码：73 / 79

页数：7

共 50 条

[1]

ALLEY MC, 1976, PHARMACOLOGIST, V18, P136

[2]

ANIKSZTEJN L, 1987, BRAIN RES, V404, P48

[3] RELEASE OF ENDOGENOUS ZN-2+ FROM BRAIN-TISSUE DURING ACTIVITY [J].

ASSAF, SY ;

CHUNG, SH .

NATURE, 1984, 308 (5961) :734-736

[4] ELECTROSHOCK-INDUCED AND PENTYLENETETRAZOL-INDUCED SEIZURES IN GENETICALLY EPILEPSY-PRONE RATS (GEPRS) - DIFFERENCES IN THRESHOLD AND PATTERN [J].

BROWNING, RA ;

WANG, C ;

LANKER, ML ;

JOBE, PC .

EPILEPSY RESEARCH, 1990, 6 (01) :1-11

[5]

CHARTON G, 1985, EXP BRAIN RES, V58, P202

[6] RADIOIMMUNOASSAY FOR MEASUREMENT OF THYROXINE IN UNEXTRACTED SERUM [J].

CHOPRA, IJ .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1972, 34 (06) :938-+

[7]

CHUNG SH, 1983, EXP NEUROL, V82, P89, DOI 10.1016/0014-4886(83)90245-5

[8] STUDIES ON SOUND-INDUCED EPILEPSY IN MICE [J].

CHUNG, SH ;

JOHNSON, MS .

PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1984, 221 (1223) :145-168

[9] LONG-TERM POTENTIATION IN THE HIPPOCAMPUS - MECHANISMS OF INITIATION AND MODULATION BY NEUROTRANSMITTERS [J].

COLLINGRIDGE, GL .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1985, 6 (10) :407-411

[10] BIDIRECTIONAL SELECTION FOR SUSCEPTIBILITY TO ETHANOL WITHDRAWAL SEIZURES IN MUS-MUSCULUS [J].

CRABBE, JC ;

KOSOBUD, A ;

YOUNG, ER ;

TAM, BR ;

MCSWIGAN, JD .

BEHAVIOR GENETICS, 1985, 15 (06) :521-536

← 1 2 3 4 5 →