THE ORGANIC-CHEMISTRY OF MECHANISM-BASED ENZYME-INHIBITION - A CHEMICAL APPROACH TO DRUG DESIGN

被引：46

作者：

SILVERMAN, RB

HOFFMAN, SJ

机构：

来源：

MEDICINAL RESEARCH REVIEWS | 1984年 / 4卷 / 03期

关键词：

D O I：

10.1002/med.2610040305

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

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页码：415 / 447

页数：33

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共 109 条

[1] SUICIDE ENZYME INACTIVATORS
ABELES, RH
MAYCOCK, AL
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1976, 9 (09) : 313 - 319
[2] S-ADENOSYLHOMOCYSTEINASE - MECHANISM OF INACTIVATION BY 2'-DEOXYADENOSINE AND INTERACTION WITH OTHER NUCLEOSIDES
ABELES, RH
FISH, S
LAPINSKAS, B
[J]. BIOCHEMISTRY, 1982, 21 (22) : 5557 - 5562
[3] ABELES RH, 1978, ENZYME ACTIVATED IRR, P1
[4] ALSTON TA, 1983, J BIOL CHEM, V258, P1136
[5] INACTIVATION OF PYRIDOXAL 5'-PHOSPHATE-DEPENDENT ENZYMES BY 5-NITRO-L-NORVALINE, AN ANALOG OF L-GLUTAMATE
ALSTON, TA
BRIGHT, HJ
[J]. FEBS LETTERS, 1981, 126 (02): : 269 - 271
[6] MECHANISM-BASED INACTIVATION OF GABA AMINOTRANSFERASE BY 3,5-DIOXOCYCLOHEXANECARBOXYLIC ACID
ALSTON, TA
PORTER, DJT
WHEELER, DMS
BRIGHT, HJ
[J]. BIOCHEMICAL PHARMACOLOGY, 1982, 31 (24) : 4081 - 4084
[7] 3-NITROPROPIONATE, TOXIC SUBSTANCE OF INDIGOFERA, IS A SUICIDE INACTIVATOR OF SUCCINATE-DEHYDROGENASE - (RAT-LIVER MITOCHONDRIA CARBANION-N-5 FLAVIN ADDUCTS 2-PROTON ABSTRACTION MECHANISM)
ALSTON, TA
MELA, L
BRIGHT, HJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (09) : 3767 - 3771
[8] INACTIVATION OF GAMMA-CYSTATHIONASE BY GAMMA-FLUORINATED AMINO-ACIDS
ALSTON, TA
MURAMATSU, H
UEDA, T
BRIGHT, HJ
[J]. FEBS LETTERS, 1981, 128 (02) : 293 - 297
[9] MECHANISM OF INACTIVATION OF TEM-1 BETA-LACTAMASE BY 6-ACETYLMETHYLENEPENICILLANIC ACID
ARISAWA, M
ADAM, S
[J]. BIOCHEMICAL JOURNAL, 1983, 211 (02) : 447 - 454
[10] BALDONI JM, 1980, J BIOL CHEM, V255, P8987

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